PT  - JOURNAL ARTICLE
AU  - Cheryl D. Wills
TI  - Barriers to Clozapine Use for Competency Restoration and the Value of Further Study
AID  - 10.29158/JAAPL.200115-20
DP  - 2021 Mar 01
TA  - Journal of the American Academy of Psychiatry and the Law Online
PG  - 49--52
VI  - 49
IP  - 1
4099  - http://jaapl.org/content/49/1/49.short
4100  - http://jaapl.org/content/49/1/49.full
SO  - J Am Acad Psychiatry Law2021 Mar 01; 49
AB  - Hospital-based restoration of adjudicative competence can be challenging, especially for patients who have treatment-resistant psychosis. Clozapine, which has helped many such individuals in the community, has not been well-studied in individuals who are incapable of proceeding with trial. In their small study, Ghossoub and colleagues have brought attention to the potential for this protocol and advocate for further study. This commentary examines potential barriers to conducting larger studies, including Institutional Review Board requirements for research with individuals who are under court supervision. Also, factors that can result in patients relapsing and being readmitted to the hospital for competency restoration due to poor treatment adherence are described. This adverse outcome burdens the judicial and health care systems and prolongs the time between the patient's arrest and trial. Clozapine may be a promising treatment for competency restoration as long as we are cognizant of barriers to further study and treatment adherence.