RT Journal Article SR Electronic T1 Effect of Clozapine on Time Assigned to Restrictive Housing in a State Prison Population JF Journal of the American Academy of Psychiatry and the Law Online JO J Am Acad Psychiatry Law FD American Academy of Psychiatry and the Law SP 581 OP 589 DO 10.29158/JAAPL.210011-21 VO 49 IS 4 A1 Theodore R. Zarzar A1 James P. Mayo III A1 David L. Rosen A1 Joseph B. Williams A1 Terri L. Catlett A1 Maria G. O'Connell A1 Genell N. Rashad A1 John G. Reed A1 Carrie L. Brown A1 Brian V. Robbins A1 Herman A. Naftel A1 Brian B. Sheitman YR 2021 UL http://jaapl.org/content/49/4/581.abstract AB This study examined the effect of clozapine on time assigned to restrictive housing (RH; i.e., solitary confinement), disciplinary infractions, and assaults on custody staff among patients treated within the North Carolina prison system. Records were reviewed for patients initiated on clozapine (n = 84) over a 3.5-year period. Fifty-nine patients completed at least three consecutive months of treatment and were included in data analysis. Assigned RH days and disciplinary infractions were assessed for the periods prior to and after treatment with clozapine. Patients accumulated 13,500 RH days pretreatment and 3,560 days postclozapine initiation. There was a significant reduction in RH days with clozapine treatment (P < .05). Patients with personality disorders (n = 36) had a significant decrease in RH days (P < .05), while those with psychotic disorders (n = 23) showed a decrease with borderline significance (P = .051). There were 253 disciplinary infractions pretreatment, including 27 assaults on custody staff, and 118 infractions posttreatment, including 7 assaults; the decrease in infractions was significant in the first three months of treatment (P < .05). The mean ± SD duration of treatment was 269 ± 102 days. Expanding clozapine use in state prisons should be a high priority, as these data are consistent with reports of clozapine's benefits in community settings.