DTI and mTBI
| Study | Participants | mTBI Criteria and/or Characteristics | DTI Timing Average (Range) | Brain Regions | Analytic Approach |
|---|---|---|---|---|---|
| 2010 | |||||
| Little et al.26 | 12 mTBI, 12 controls | ACRM mTBI criteria | >12 months | VA thalamic nucleus | ROI analysis: FA |
| Geary et al.27 | 40 mTBI, 35 controls | ACRM mTBI criteria | 5.29 years | SLF, SS, UF | ROI analysis: FA |
| Levin et al.28 | 32 mTBI, 15 controls (8 healthy, 7 extracranial injury) | OEF/OIF veterans with blast injury, 32 mild plus 5 moderate TBIs, essentially ACRM criteria | 871.5 days | No group differences in FA or ADC | Tractography, ROI, and voxel-based analysis: FA, ADC |
| Mayer et al.29 | 22 mTBI, 21 controls | ACRM mTBI criteria | 12.5 days (2–20) | CC, CR, UF | ROI analysis: FA, AD, RD |
| 2009 | |||||
| Chu et al.30 | 10 mTBI, 10 controls | Initial GCS 15, negative CT, otherwise not reported | 2.7 days (1–6) | Left thalamus, scattered white matter | Whole-brain voxel-wise analysis: ADC,FA, AD |
| Wu et al.31 | 12 mTBI, 11 controls | GCS of 15 in ED and +LOC (<10 min) | 2.92 days (1–6) | CB | ROI analysis: FA, ADC |
| Lipton et al.4 | 20 mTBI, 20 controls | GCS ≤ 13, LOC < 20 min, PTA < 24 hr | (2–14 days) | Frontal white matter (DLPFC) | Whole-brain voxel-wise analysis: FA, MD |
| Kumar et al.32 | 26 mTBI, 33 controls | GCS 13–15, all + LOC (<20 min), all + CT | 8.9 days (5–14) | CC | ROI analysis: FA, MD, AD, RD |
| Huang et al.33 | 10 mTBI, 14 controls | LOC < 15 min, GCS 13–15, PTA < 24 hr, persistent PCS | (1–46 months) | ILF, SLF, temporal, parietal, occipital, frontal | Whole-brain voxel-wise analysis: FA |
| Lo et al.34 | 10 mTBI, 10 controls | GCS ≥ 13, persistent cognitive impairment | (>2 yrs) | CC, IC | ROI analysis: FA, ADC |
| 2008 | |||||
| Lipton et al.35 | 17 mTBI, 10 controls | GCS ≥ 13, LOC < 20 min, PTA < 24 hr, persistent cognitive impairment | (8 months to 3 years) | CC, subcortical white matter, IC | Whole-brain voxel-wise analysis: FA, MD |
| Niogi et al.36 | 43 mTBI, 23 controls | GCS ≥ 13, +PTA | 16.9 months (1–53 months) | Corona radiata, UF | ROI analysis: FA |
| Rutgers et al.37 | 24 mild TBI, 10 controls | GCS ≥13 | 2.8 months (0.4–26.2) | CC | ROI analysis: FA, ADC |
| Wilde et al.38 | 10 mTBI, 10 controls | GCS of 15 in ED and +LOC (<10 min) | 2.7 days (1–6) | CC | Whole CC analysis: FA, ADC, RD |
| Niogi et al.39 | 34 mTBI, 26 controls | GCS 13–15, +LOC,+PTA, ≥1 post concussive symptom | (1–65 months) | Anterior corona radiate, UF, CC, ILF, CB | ROI analysis: FA |
| Miles et al.40 | 17 mTBI, 29 controls | GCS 13–15, LOC < 20 min, PTS < 24 hr | 4 days (1–10) | CS, CC, posterior limb IC | ROI analysis: MD, FA |
| Rutgers et al.41 | 21 mTBI, 11 controls | GCS ≥13 | 5.5 months (0.1–109.3 months) | Cerebral lobar white matter, cingulum, CC | Whole-brain voxel-wise analysis: FA, ADC |
| 2007 | |||||
| Bazarian et al.42 | 6 mTBI, 6 orthopedic controls | GCS 13–15, +LOC or amnesia | ≤72 hours | Left anterior IC, posterior CC | ROI and whole-brain analysis: trace, FA |
| Kraus7 | 20 mTBI, 18 controls | ACRM mTBI criteria | 107 months | CST, SS | White matter load and ROI analysis: FA, AD, RD |
| Hashimoto et al.43 | 1 mTBI (case report) | GCS 13 at 30 min | 3 years | CC, cingulate, prefrontal area | MR tractography |
| Wozniak et al.44 | 6 mTBI, 14 controls | LOC, PTA, altered MS, recurrent emesis or persistent headache, or transient focal neurological deficits + GCS 13–15 | 8.2 months | Supracallosal | ROI analysis: FA |
| Benson et al.45 | 6 mTBI, 14 controls | LOC or PTA + GCS 13–15, 4/6 with +CT findings | 35.3 months (3 days–15 years) | Global white matter | Global white matter histogram analysis: FA |
| 2002–2005 | |||||
| Inglese et al.46 | 46 mTBI, 29 controls | ACRM mTBI criteria | 4.05 days for 20 subjects, 5.7 years for 26 | CC, IC, CS, | Whole brain histogram and ROI analysis: FA, MD |
| Arfanakis et al.47 | 5 mTBI, 10 controls | Amnesia, disorientation, or confusion + GCS 13–15 | <24 hours | CC, IC, EC | ROI analysis: FA, LI |
VA, ventral anterior; CB, cingulum bundle; DLPFC, dorsolateral prefrontal cortex; CC, corpus callosum; ILF, inferior longitudinal fasciculus; SLF, superior longitudinal fasciculus; IC, internal capsule; UF, uncinate fasciculus; CS, centra semiovale; CST, corticospinal tract; SS, sagittal stratum; EC, external capsule.