Original articleSubstance abuse and the onset of schizophrenia
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Cited by (290)
Substance misuse and social cognition on the psychosis-spectrum: A bottom-up framework
2019, Social Cognition in PsychosisThe link between schizophrenia and substance use disorder: A unifying hypothesis
2018, Schizophrenia ResearchCitation Excerpt :Patients with schizophrenia are quite vulnerable to substance use disorders (Regier et al., 1990; Stinson et al., 2006); according to the Epidemiological Catchment Area study, 47% of patients with schizophrenia have serious problems with drug or alcohol use during their lifetime compared to 16% of the general population. Regarding specific substances: tobacco, alcohol, cannabis and cocaine use disorders occur commonly in patients with schizophrenia (Mueser et al., 1990; Volkow, 2009), with lifetime prevalence ranging from 60 to 90% for cigarette smoking, as well as 21–86% for alcohol (Volkow, 2009), 17–83% for cannabis (Degenhardt and Hall, 2001; DeQuardo et al., 1994; Dixon et al., 1991; Hambrecht and Hafner, 1996; Karam et al., 2002; Mueser et al., 1995; Perala et al., 2007; Peralta and Cuesta, 1992; Ringen et al., 2008; Volkow, 2009) and 15–50% for cocaine use (Chambers et al., 2001; Mueser et al., 1990) – rates at-least three-times greater than those in the general population (Regier et al., 1990). Importantly, in this population, such high rates of substance use disorders are problematic: co-occurring substance use disorder has been associated with clinical exacerbations, non-compliance with treatment, poor global functioning, violence, suicide and increased rates of relapse and re-hospitalization (DeQuardo et al., 1994; Dickey and Azeni, 1996; Henquet et al., 2010; Juckel et al., 2006; Kivlahan et al., 1991; Knudsen and Vilmar, 1984; Linszen et al., 1994; Negrete and Knapp, 1986; Peralta and Cuesta, 1992; Regier et al., 1990; Sayers et al., 2005; Smith et al., 1997; Swendsen et al., 2011; Treffert, 1978; van Dijk et al., 2012).
Unique Effects of Clozapine: A Pharmacological Perspective
2018, Advances in PharmacologyCannabis use related to early psychotic onset: Role of premorbid function
2016, Neuroscience LettersDifferential effects of sex on substance use between first episode psychosis patients and healthy people
2016, Comprehensive Psychiatry
The Deutsche Forschungsgemeinschaft (German Research Association) supported this study within the Sonderforschungsbereich (Special Research Branch) 258.