Original articleSize Versus Shape Differences: Contrasting Voxel-Based and Volumetric Analyses of the Anterior Cingulate Cortex in Individuals with Acute Posttraumatic Stress Disorder
Section snippets
Subjects and Procedure
Trauma-exposed participants (n = 14) were recruited in the emergency department of three hospitals from the greater Montreal area. Nurses from these departments approached individuals who had suffered a traumatic experience and invited these individuals to call our team. It was thus the victim’s choice to contact our research team for further information. Although we had planned to use a three-group design (trauma-exposed individuals with and without PTSD and control subjects with a negative
Sociodemographic
More than 50% of the participants were motor vehicle accident victims. As can be seen in Table 1, participants from the trauma-exposed group reported high levels of peritraumatic distress and peritraumatic dissociation, consistent with what others have found (see Brunet et al 2001) and were highly symptomatic in terms of PTSD symptoms. The ratios of male to female (6 to 8) and right-handed to left-handed (11 to 3) were the same in both groups. As expected, the groups differed on depressive
Discussion
This study investigated possible morphological differences in the ACC of normal control subjects compared with individuals with acute PTSD using voxel-based morphometry, manual segmentation, and probabilistic maps. Our VBM finding of a reduced gray matter density in the dorsal ACC in PTSD individuals is consistent with the results of Yamasue et al (2003), although they were found in opposite hemispheres. In addition, our VBM analyses also detected a significant difference in the left insula, a
References (44)
- et al.
rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest
Biol Psychiatry
(2002) - et al.
MRI-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuseA preliminary report
Biol Psychiatry
(1997) - et al.
Neural correlates of exposure to traumatic pictures and sounds in Vietnam combat veterans with and without posttraumatic stress disorderA positron emission tomography study
Biol Psychiatry
(1999) - et al.
Neural correlates of the classic color and emotional Stroop in women with abuse-related posttraumatic stress disorder
Biol Psychiatry
(2004) - et al.
Cognitive and emotional influences in anterior cingulate cortex
Trends Cogn Sci
(2000) - et al.
A functional neuroanatomy of anticipatory anxiety
Neuroimage
(1999) - et al.
Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatmentA positron emission tomography provocation study
Neurosci Lett
(2001) - et al.
Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder
Biol Psychiatry
(2004) - et al.
Magnetic resonance imaging study of hippocampal volume in chronic, combat-related post-traumatic stress disorder
Biol Psychiatry
(1996) - et al.
Brain activation during script-driven imagery induced dissociative responses in PTSDA functional magnetic resonance imaging investigation
Biol Psychiatry
(2002)
Recall of emotional states in posttraumatic stress disorderAn fMRI investigation
Biol Psychiatry
Brain activation in PTSD in response to trauma-related stimuli
Biol Psychiatry
Neurobiology of emotion perception IThe neural basis of normal emotion perception
Biol Psychiatry
Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorderA functional MRI study
Biol Psychiatry
An fMRI study of anterior cingulate function in posttraumatic stress disorder
Biol Psychiatry
Regional frontal cortical volumes decrease differentially in agingAn MRI study to compare volumetric approaches and voxel-based morphometry
Neuroimage
The anterior cingulate cortexEvolution of an interface between emotion and cognition
Ann N Y Acad Sci
An inventory for measuring depression
Arch Gen Psychiatry
The development of a clinician administered PTSD scale
J Trauma Stress
Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder
Am J Psychiatry
MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder
Am J Psychiatry
Cited by (112)
Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis
2021, Neuroscience and Biobehavioral ReviewsA unifying translational framework to advance treatment research for comorbid PTSD and substance use disorders
2021, Neuroscience and Biobehavioral ReviewsGenomics and proteomics in brain complexity in relation to chemically induced posttraumatic stress disorder
2020, Handbook of Toxicology of Chemical Warfare Agents