Archival ReportGenome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder
Section snippets
Subjects
A total of 9340 subjects (GWAS: n = 5799, replication: n = 3541) were recruited for genetic studies of alcohol, cocaine, and opioid dependence at five US sites using similar methodologies: Yale University School of Medicine (GWAS: n = 2360, replication: n = 1737), the University of Connecticut Health Center (GWAS: n = 2303, replication: n = 1360), the University of Pennsylvania School of Medicine (GWAS: n = 476, replication: n = 228), the Medical University of South Carolina (GWAS: n = 459,
Results
After quality control of the GWAS data and removal of the related subjects, 1633 EAs and 2847 AAs were retained. We further removed 55 EAs and 81 AAs with unknown lifetime PTSD diagnosis. Final GWAS analyses included 1578 EAs (300 PTSD cases) and 2766 AAs (444 PTSD cases). Demographic information of the subjects is listed in Table 1.
In EAs and AAs, 768,146 and 870,103 SNPs, respectively, passed quality control steps. Based on Bonferroni correction for multiple comparisons, the threshold of
Discussion
In this study, we performed GWAS analyses of PTSD in 1578 EAs (300 PTSD cases) and 2766 AAs (444 PTSD cases). In the primary analyses in EAs, we observed genome-wide significant evidence of association to that trait for one SNP located on chromosome 7p12, rs406001. Two other SNPs in the same region, rs382903 and rs450378, were the second and fourth most significant SNPs. The region showing the second strongest evidence of association was the first intron of TLL1 where three SNPs, rs6812849,
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