Regular Research ArticlePsychosis of Alzheimer Disease: Prevalence, Incidence, Persistence, Risk Factors, and Mortality
Section snippets
Study Design
Cohort study with cross-sectional and longitudinal components.
Results
The sample consisted of 491 patients, of whom 70.9% (n = 348) were women and 40.1% (n = 197) were younger than 75 years (mean: 75.2 years; SD: 6.6 years; range: 52–89 years). The mean number of years of education was 5.9 (SD: 3.7; range: 0–21). The mean score on the CAMCOG was 55.6 points (SD: 13.4; range: 14–88) and 10.1 points for the NPI (SD: 11.4; range: 0–77). The mean time since dementia onset was 32.5 months (SD: 27.4; range: 2–170), and 25.6% (n = 126) of the subjects had a history of a
Conclusions
Questions exist regarding the homogeneity of PoAD, because subgroups of patients with psychotic symptoms have been observed to have different characteristics regarding the kind of psychotic symptoms and other clinical variables.25 The differences observed in patients with delusions and without hallucinations and patients with hallucinations2 give rise to questions regarding the validity of PoAD. Note that varied clinical situations may be observed, all of which include psychotic symptoms that
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2020, Handbook of Clinical NeurologyCitation Excerpt :A literature review of human mortality in AD consistently shows higher male mortality (or female longevity) in developed nations worldwide. In longitudinal studies with over 100 individuals and some measure of disease onset, males with AD showed higher risk of mortality than females with AD in the United States (Heyman et al., 1987; Beard et al., 1994; Stern et al., 1995, 1997; Aneshensel et al., 2000; Williams et al., 2006), Canada (Wolfson et al., 2001), England (Burns et al., 1991), Italy (Bracco et al., 1994), Scotland (Thomas et al., 1997), the Netherlands (Claus et al., 1999), Spain (Vilalta-Franch et al., 2013), Germany (Roehr et al., 2015), and South Korea (Go et al., 2013). Since populations in developing nations are living longer, and AD is now an increasingly frequent and recognized problem, future studies will identify whether increased male mortality also extends to developing nations that include additional ancestry and genetic variation.
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2018, American Journal of Geriatric PsychiatryCitation Excerpt :These findings are consistent with previous research,1,3,6 though not all studies have found an association with institutionalization.7 Neither symptom, however, was associated with mortality, contrary to some previous findings that have examined the symptoms together.8 Nevertheless, use of antipsychotic medication was associated with greater mortality, which is consistent with previous research, including both observational and randomized controlled studies.31–37