Abstract
Objective:
The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia.
Method:
Spatial working memory performance was evaluated at baseline and after 17 and 29 weeks in 97 patients with schizophrenia participating in a multisite trial.
Results:
Compared with baseline performance while receiving conventional antipsychotic medication, risperidone improved, and clozapine worsened, spatial working memory performance.
Conclusions:
The differential effects of these medications on spatial working memory may be due to the anticholinergic effects of clozapine and prefrontal dopamine-enhancing effects of risperidone.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Antipsychotic Agents / pharmacology*
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Antipsychotic Agents / therapeutic use*
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Brief Psychiatric Rating Scale
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Clozapine / pharmacology*
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Clozapine / therapeutic use*
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Diagnosis, Computer-Assisted
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Double-Blind Method
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Female
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Follow-Up Studies
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Humans
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Male
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Memory / drug effects*
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Memory Disorders / diagnosis
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Memory Disorders / physiopathology
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Middle Aged
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Neuropsychological Tests*
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Prefrontal Cortex / drug effects
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Prefrontal Cortex / physiopathology
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Psychomotor Performance / drug effects
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Psychotic Disorders / diagnosis
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Psychotic Disorders / drug therapy
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Psychotic Disorders / physiopathology
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Risperidone / pharmacology*
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Risperidone / therapeutic use*
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Schizophrenia / diagnosis
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Schizophrenia / drug therapy*
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Schizophrenia / physiopathology
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Schizophrenic Psychology*
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Space Perception / drug effects*
Substances
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Antipsychotic Agents
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Clozapine
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Risperidone