In an effort to reduce injuries and prevent deaths from violence, interprofessional domestic violence fatality review teams (DVFRT) have developed across the United States and globally to study factors that contribute to intimate partner injury and deaths. Drawing upon knowledge from the disciplines of health, education, criminal justice, social services, and policy, these teams review and analyze domestic violence homicide cases to uncover basic knowledge about causes, factors that increase or decrease the risk for death and injury, and specific ways to prevent further injury and death. Through interprofessional collective recommendations and cooperative actions, these teams are developing promising practices and systems' changes that offer better services, learning, and interventions to reduce injury and death from domestic violence.