Abstract
The cerebellar cognitive affective syndrome (CCAS) represents a spectrum of cerebellar-induced neurocognitive and affective disturbances. In this report a patient is described who developed CCAS under a treatment with standard daily dose of the anti-epileptic drug topiramate (TPM). Cognitive disturbances consisted of impaired visuo-spatial memory, concentration deficits and executive dysfunctions. Behavior and affect were characterized by marked mood-swings and several disinhibited symptoms. After a gradual discontinuation of treatment with topiramate, a complete remission of the cognitive and affective symptoms was observed within 6 weeks. Functional neuroimaging studies by means of SPECT were conducted 2 weeks and 8 months following TPM discontinuation. This case report seems to suggest that functional disruption of the cerebello-cerebral circuitry, leading to CCAS, can follow treatment with topiramate.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / administration & dosage
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Anticonvulsants / administration & dosage
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Anticonvulsants / adverse effects*
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Carbamazepine / administration & dosage
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Carbamazepine / analogs & derivatives
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Cerebellar Diseases / chemically induced*
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Cerebellar Diseases / complications
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Cerebellum / drug effects
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Cognition Disorders / chemically induced*
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Cognition Disorders / complications
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Cyclohexanecarboxylic Acids / administration & dosage
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Drug Therapy, Combination
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Epilepsy / complications
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Epilepsy / drug therapy
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Female
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Follow-Up Studies
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Fructose / administration & dosage
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Fructose / adverse effects
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Fructose / analogs & derivatives*
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Gabapentin
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Humans
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Middle Aged
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Mood Disorders / chemically induced*
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Mood Disorders / complications
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Neuropsychological Tests
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Oxcarbazepine
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Syndrome
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Topiramate
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Treatment Outcome
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gamma-Aminobutyric Acid / administration & dosage
Substances
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Amines
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Anticonvulsants
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Cyclohexanecarboxylic Acids
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Topiramate
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Fructose
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Carbamazepine
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gamma-Aminobutyric Acid
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Gabapentin
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Oxcarbazepine