Abstract
The cardiac effects of lithium and carbamazepine are considered rare, but both are known to induce sinus node dysfunction. The author presents the 9-year experience in a state mental hospital with lithium-induced sinus node dysfunction. Four of the five patients were also on carbamazepine. The clinical features of previously reported cases of lithium- and carbamazepine-associated sinus node dysfunction are reviewed. A role for carbamazepine in lithium-induced sinus node dysfunction is discussed.
MeSH terms
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Adult
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Aged
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Bipolar Disorder / blood
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Bipolar Disorder / drug therapy*
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Bipolar Disorder / psychology
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Carbamazepine / administration & dosage
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Carbamazepine / adverse effects*
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Carbamazepine / pharmacokinetics
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Dose-Response Relationship, Drug
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Drug Synergism
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Drug Therapy, Combination
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Electrocardiography / drug effects
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Female
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Humans
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Intellectual Disability / blood
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Intellectual Disability / drug therapy*
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Intellectual Disability / psychology
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Lithium Carbonate / administration & dosage
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Lithium Carbonate / adverse effects*
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Lithium Carbonate / pharmacokinetics
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Male
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Middle Aged
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Neurocognitive Disorders / blood
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Neurocognitive Disorders / drug therapy*
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Neurocognitive Disorders / psychology
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Sick Sinus Syndrome / blood
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Sick Sinus Syndrome / chemically induced*
Substances
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Lithium Carbonate
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Carbamazepine