A Whole-Genome Assembly of Drosophila
…, RA Bolanos, HH Chou, CM Jordan, AL Halpern… - Science, 2000 - science.org
We report on the quality of a whole-genome assembly ofDrosophila melanogaster and the
nature of the computer algorithms that accomplished it. Three independent external data …
nature of the computer algorithms that accomplished it. Three independent external data …
Environmental genome shotgun sequencing of the Sargasso Sea
JC Venter, K Remington, JF Heidelberg, AL Halpern… - science, 2004 - science.org
We have applied “whole-genome shotgun sequencing” to microbial populations collected
en masse on tangential flow and impact filters from seawater samples collected from the …
en masse on tangential flow and impact filters from seawater samples collected from the …
[HTML][HTML] Evolution of genes and genomes on the Drosophila phylogeny
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves
the precision and sensitivity of evolutionary inference, producing more robust results than …
the precision and sensitivity of evolutionary inference, producing more robust results than …
[HTML][HTML] The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific
The world's oceans contain a complex mixture of micro-organisms that are for the most part,
uncharacterized both genetically and biochemically. We report here a metagenomic study of …
uncharacterized both genetically and biochemically. We report here a metagenomic study of …
[HTML][HTML] The diploid genome sequence of an individual human
… In this analysis, the 216,179 deletions and 177,320 insertions from Mills et al. [55] were
compared to the insertions and deletions identified from the HuRef assembly. Based on this …
compared to the insertions and deletions identified from the HuRef assembly. Based on this …
Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays
R Drmanac, AB Sparks, MJ Callow, AL Halpern… - Science, 2010 - science.org
Genome sequencing of large numbers of individuals promises to advance the understanding,
treatment, and prevention of human diseases, among other applications. We describe a …
treatment, and prevention of human diseases, among other applications. We describe a …
Evolutionary and biomedical insights from the rhesus macaque genome
…, CS White, AT Chinwalla, Y Feng, AL Halpern… - science, 2007 - science.org
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from
the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and …
the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and …
[HTML][HTML] The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families
Metagenomics projects based on shotgun sequencing of populations of micro-organisms
yield insight into protein families. We used sequence similarity clustering to explore proteins …
yield insight into protein families. We used sequence similarity clustering to explore proteins …
Strelka2: fast and accurate calling of germline and somatic variants
We describe Strelka2 ( https://github.com/Illumina/strelka ), an open-source small-variant-calling
method for research and clinical germline and somatic sequencing applications. …
method for research and clinical germline and somatic sequencing applications. …
The dog genome: survey sequencing and comparative analysis
EF Kirkness, V Bafna, AL Halpern, S Levy… - Science, 2003 - science.org
A survey of the dog genome sequence (6.22 million sequence reads; 1.5× coverage)
demonstrates the power of sample sequencing for comparative analysis of mammalian genomes …
demonstrates the power of sample sequencing for comparative analysis of mammalian genomes …