Many excellent and up to date reviews on kinase inhibitors exist, and this area certainly
does not meet the normal criteria for a Chemical Reviews article. However, most of these …

Septins are GTP-binding proteins that form filaments and higher-order structures on the cell
cortex of eukaryotic cells and associate with actin and microtubule cytoskeletal networks. …

The mitogen-activated protein kinase pathway is thought to be essential in cellular growth
and differentiation. Here we report the discovery of a highly potent and selective inhibitor of …

Compartmentalization in cells is central to the spatial and temporal control of biochemistry.
In addition to membrane-bound organelles, membrane-less compartments form partitions in …

Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with
congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly …

Pornography has become a primary source of sexual education. At the same time, mainstream
commercial pornography has coalesced around a relatively homogenous script involving …

Bacteria orchestrate collective behaviors and accomplish feats that would be unsuccessful if
carried out by a lone bacterium. Processes undertaken by groups of bacteria include …

Cytochrome P450 2D6 is a heme-containing enzyme that is responsible for the metabolism
of at least 20% of known drugs. Substrates of 2D6 typically contain a basic nitrogen and a …

ZO-1 binds numerous transmembrane and cytoplasmic proteins and is required for
assembly of both adherens and tight junctions, but its role in defining barrier properties of an …

Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads
to activation of mitogen-activated protein kinases (MAPKs, also called extracellular signal…