Solid-state reactions that occur in drug substances and formulations include solid-state phase
transformations, dehydration/desolvation, and chemical reactions. Chemical reactivity is …

The solid form of a drug substance is important when developing a new chemical entity. The
crystalline form used in development is significant based on possible manufacturability, …

A general review of the methods available for the physical characterization of pharmaceutical
solids is presented. The techniques are classified as being on the molecular level (…

A general method was developed to select the optimal salt form for BMS-180431, a novel
HMG-CoA reductase inhibitor and a candidate for oral dosage form development, in an …

The amount of water vapor taken up by an active pharmaceutical ingredient (API) as a
function of relative humidity is routinely evaluated to characterize and monitor its “hygroscopicity” …

Objective To compare the effect of sentinel lymph node (SLN) histology vs locoregional
lymph node (LRLN) fine needle aspiration (FNA) cytology on assigned disease stage and …

A variety of techniques can be used to characterize the physical properties of pharmaceutical
solids, including thermal analysis, hot-stage microscopy, X-ray powder diffraction, …

Overmixing of magnesium stearate with granules in the hopper of a capsule filling machine
can slow down their dissolution because of coating by magnesium stearate, which acts as a …

Objective: The objective of this study was to assess attitudes of patrons and medical school
faculty about physicians with nontraditional facial piercings. We also examined whether a …

Although bedrock weathering strongly influences water quality and global carbon and nitrogen
budgets, the weathering depths and rates within subsurface are not well understood nor …