A clinical isolate of Klebsiella ozaenae with transferable resistance to broad-spectrum
cephalosporins produces a beta-lactamase determined by plasmid pBP60. The beta-lactamase …

… cerevisiae as described in the work of Wiedemann and Boles (35) and cloned into the
vector p426H7 by recombination cloning as described above. Using the coding region of C. …

In this study, we analyzed the mechanisms of multiresistance for 22 clinical multiresistant and
clonally different Pseudomonas aeruginosa strains from Germany. Twelve and 10 strains …

Rationale: Lower airway (LAW) infection with Pseudomonas aeruginosa and Staphylococcus
aureus is the leading cause of morbidity in cystic fibrosis (CF). The upper airways (UAW) …

Objective To investigate the natural susceptibility to 71 antimicrobial agents of 103 Listeria
strains belonging to all known Listeria species (L. monocytogenes (N = 21), L. innocua (N = 21…

… This high efficacy is due to the high affinity and inhibitory activity of the drugs to their target
topoisomerases gyrase and topoisomerase IV which are A 2 B 2 tetrameric enzymes sharing …

… Hüllen V., Heisig P., and Wiedemann B. Role of marR mutations in the development of
clinical resistance of Escherichia coli against fluoroquinolones, abstr. C-64 Abstracts of the 37th …

After 60 years of antibiotic treatment, attempts to rationalize it have culminated in the use of
pharmacological indices. These indices facilitate comparison of the activity of different …

Two mechanisms of resistance to fluoroquinolones are known: (i) alteration of the molecular
target of quinolone action — DNA gyrase, and (ii) reduction of the quinolone accumulation. …

Purpose In patients with acute myeloid leukemia (AML), differential indications for matched
sibling and unrelated hematopoietic stem-cell transplantation (HCT) are considered, and …