Objectives The purpose of this study was to determine whether apoptosis is a major mechanism
of cell death in patients with sepsis. The activities of caspase-3 and the antiapoptotic …

Patients with sepsis have impaired host defenses that contribute to the lethality of the
disorder. Recent work implicates lymphocyte apoptosis as a potential factor in the …

This issue of Critical Care Medicine reports the results of the second phase III double-blinded
multicenter trial of interleukin-1 receptor antagonist (IL-1ra)[1]. In a clear presentation and …

Study objectives Tracheostomy is one of the mostcommonly performed procedures in the
patient receiving long-termmechanical ventilation. While percutaneous dilational tracheostomy(…

Objective: To perform a systematic review and meta-analysis of studies comparing operative
to nonoperative therapy in adult FC patients. Outcomes were duration of mechanical …

… Freeman BD, Isabella K, Lin N, et al: A meta-analysis of prospective trials comparing
percutaneous and surgical tracheostomy in critically ill patients. Chest 2000; 118: 1421–1418 …

Objective Apoptosis is a cellular suicide program that can be activated by cell injury or stress.
Although a number of laboratory studies have shown that ischemia/reperfusion injury can …

Objective: Tracheostomy remains one of the most commonly performed surgical procedures
in adults with acute respiratory failure and identifies a patient cohort which is among the …

Objective: Tracheostomy practice in the setting of critical illness is controversial because
evidence demonstrating unequivocal benefit is lacking. We undertook this study to determine …

Despite advances in supportive care, the morbidity and mortality rate resulting from sepsis
and septic shock remain high (30 - 50%). A central hypothesis driving sepsis research in …