International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone …
NZ Lu, SE Wardell, KL Burnstein, D Defranco… - Pharmacological …, 2006 - ASPET
The glucocorticoid receptor (GR1), mineralocorticoid receptor (MR), progesterone receptor (PR),
and androgen receptor (AR) are classic members of the nuclear receptor superfamily, …
and androgen receptor (AR) are classic members of the nuclear receptor superfamily, …
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement
WB Pratt, MD Galigniana, JM Harrell, DB DeFranco - Cellular signalling, 2004 - Elsevier
The ubiquitous protein chaperone hsp90 has been shown to regulate more than 100 proteins
involved in cellular signalling. These proteins are called ‘client proteins’ for hsp90, and a …
involved in cellular signalling. These proteins are called ‘client proteins’ for hsp90, and a …
Oxidative neuronal injury: the dark side of ERK1/2
…, EM Chalovich, DB DeFranco - European Journal of …, 2004 - Wiley Online Library
The extracellular signal regulated protein kinases (ERK1/2) are essential for normal development
and functional plasticity of the central nervous system. However, a growing number of …
and functional plasticity of the central nervous system. However, a growing number of …
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled …
…, V Nagaraja, L Cholewa, D DiFranco… - The Lancet …, 2023 - thelancet.com
Background Interstitial lung disease is a known complication of rheumatoid arthritis, with a
lifetime risk of developing the disease in any individual of 7·7%. We aimed to assess the safety…
lifetime risk of developing the disease in any individual of 7·7%. We aimed to assess the safety…
Interaction between endothelium and CD4+ CD45RA+ lymphocytes. Role of the human CD38 molecule.
U Dianzani, A Funaro, D DiFranco… - … (Baltimore, Md.: 1950 …, 1994 - journals.aai.org
CD38 is a type II transmembrane glycoprotein, which is widely used as a marker for immature
and activated lymphocytes, as well as plasma cells. Although its functional role and natural …
and activated lymphocytes, as well as plasma cells. Although its functional role and natural …
Deficiency of the Fas apoptosis pathway without Fas gene mutations in pediatric patients with autoimmunity/lymphoproliferation
U Dianzani, M Bragardo, D DiFranco… - Blood, The Journal …, 1997 - ashpublications.org
… -Fas MoAb + anti-IgM serum (lanes c and d), and cell survival was assessed after 18 (lanes
a and c) or 48 hours (lanes b and d) by the trypan blue exclusion test. Results are expressed …
a and c) or 48 hours (lanes b and d) by the trypan blue exclusion test. Results are expressed …
Deficiency of the Fas apoptosis pathway without Fas gene mutations is a familial trait predisposing to development of autoimmune diseases and cancer
…, F Bottarel, C Gambaruto, D DiFranco… - Blood, The Journal …, 2000 - ashpublications.org
Fas/Apo-1 (CD95) triggers programmed cell death (PCD) and is involved in immune response
control and cell-mediated cytotoxicity. In the autoimmune/lymphoproliferative syndrome (…
control and cell-mediated cytotoxicity. In the autoimmune/lymphoproliferative syndrome (…
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1
CJ Cummings, MA Mancini, B Antalffy, DB DeFranco… - Nature …, 1998 - nature.com
… The staining for the proteasome in cerebellar tissue from nontransgenic mice (c) and mice
expressing a wild-type ataxin-1 with 30 glutamines (d) is diffuse in the nuclei of Purkinje cells. …
expressing a wild-type ataxin-1 with 30 glutamines (d) is diffuse in the nuclei of Purkinje cells. …
[HTML][HTML] Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures
…, MR Angiolieri, JW Johnson, DB DeFranco - Journal of Biological …, 2000 - ASBMB
Oxidative stress can trigger neuronal cell death and has been implicated in several chronic
neurological diseases and in acute neurological injury. Oxidative toxicity can be induced by …
neurological diseases and in acute neurological injury. Oxidative toxicity can be induced by …
Situated and interactive multimodal conversations
… 8 in Appendix D. First, the tensor ut is transformed into a vector qt ∈ RNH through self-… (d)
The confusion matrix for HRE on SIMMC-Furniture (Appendix F) reveals a high … D API Call List …
The confusion matrix for HRE on SIMMC-Furniture (Appendix F) reveals a high … D API Call List …