User profiles for D. Keith Williams
 | David Keith WilliamsUniversity of Arkansas for Medical Sciences Verified email at uams.edu Cited by 11952 |
Cytochrome P450 phenotypic ratios for predicting herb‐drug interactions in humans
…, SF Gardner, MA Hubbard, DK Williams… - Clinical …, 2002 - Wiley Online Library
Objectives Phytochemical‐mediated modulation of cytochrome P450 (CYP) activity may
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes
…, SF Gardner, MA Hubbard, DK Williams… - Clinical …, 2005 - Wiley Online Library
Objectives Phytochemical‐mediated modulation of cytochrome P450 (CYP) activity may
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba
BJ Gurley, SF Gardner, MA Hubbard, DK Williams… - Drugs & aging, 2005 - Springer
Objectives Elderly patients are more likely to ingest prescription medications concurrently
with botanical supplements, and may therefore be vulnerable to herb-drug interactions. …
with botanical supplements, and may therefore be vulnerable to herb-drug interactions. …
In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto
…, SF Gardner, MA Hubbard, DK Williams… - Clinical …, 2004 - Wiley Online Library
Objectives Phytochemical‐mediated modulation of cytochrome P450 (CYP) activity may
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
underlie many herb‐drug interactions. Single‐time point phenotypic metabolic ratios were used …
Clinical assessment of CYP2D6‐mediated herb–drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and …
…, A Swain, MA Hubbard, DK Williams… - Molecular nutrition & …, 2008 - Wiley Online Library
Cytochrome P450 2D6 (CYP2D6), an important CYP isoform with regard to drug–drug
interactions, accounts for the metabolism of ∼︁30% of all medications. To date, few studies have …
interactions, accounts for the metabolism of ∼︁30% of all medications. To date, few studies have …
[HTML][HTML] The effects of hypercapnia on cerebral autoregulation in ventilated very low birth weight infants
JR Kaiser, CH Gauss, DK Williams - Pediatric research, 2005 - nature.com
Permissive hypercapnia, a strategy allowing high Paco 2, is widely used by neonatologists
to minimize lung damage in ventilated very low birth weight (VLBW) infants. While …
to minimize lung damage in ventilated very low birth weight (VLBW) infants. While …
Gauging the clinical significance of P‐glycoprotein‐mediated herb‐drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on …
BJ Gurley, A Swain, DK Williams… - Molecular nutrition & …, 2008 - Wiley Online Library
Concomitant administration of botanical supplements with drugs that are P‐glycoprotein (P‐gp)
substrates may produce clinically significant herb‐drug interactions. This study …
substrates may produce clinically significant herb‐drug interactions. This study …
Cost-effectiveness analysis of a rural telemedicine collaborative care intervention for depression
…, MJ Edlund, DK Williams - Archives of general …, 2010 - jamanetwork.com
Context Collaborative care interventions for depression in primary care settings are clinically
beneficial and cost-effective. Most prior studies were conducted in urban settings. Objective …
beneficial and cost-effective. Most prior studies were conducted in urban settings. Objective …
Pancreatitis: prevalence and risk factors among male veterans in a detoxification program
D Yadav, ML Eigenbrodt, MJ Briggs, DK Williams… - Pancreas, 2007 - journals.lww.com
Objectives: To determine the prevalence of pancreatitis and associated risk factors among
heavy-drinking veterans. Methods: At a large Veterans Administration Outpatient …
heavy-drinking veterans. Methods: At a large Veterans Administration Outpatient …
Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans
BJ Gurley, GW Barone, DK Williams, J Carrier… - Drug metabolism and …, 2006 - ASPET
Phytochemical-mediated modulation of P-glycoprotein (P-gp) and other drug transporters
may underlie many herb-drug interactions. Serial serum concentration-time profiles of the P-gp …
may underlie many herb-drug interactions. Serial serum concentration-time profiles of the P-gp …