• Considerable evidence suggests that the acute effects of antidepressant treatments on brain
norepinephrine (NE) and serotonin (5-HT) systems cannot account fully for their delayed …

Methods Having criticised the way in which Keller et al interpreted the results of their study, 3
4 we sought to check the quality of methods and reporting of other published trials of newer …

The dietary technique of acute tryptophan depletion was used to suppress brain serotonin
synthesis in 16 women with documented premenstrual syndrome. Each subject was tested at …

Objectives Psychogenic nonepileptic seizures (PNESs) are closely linked with psychological
distress, but their etiology is not well-understood. We reviewed psychiatric comorbidity in …

The behavior of rats with selective lesions of either the dorsal (B7), median (B8), or lateral (B9)
raphe nuclei was compared to that of sham-lesioned controls in a variety of experimental …

SURROGATE OUTCOMES are often used as prox-ies for hard clinical out-comes, as they
enable smaller, faster, and thus cheaper clinical trials. In addition, pharmaceutical companies …

… David B Menkes … David B Menkes … Citation: Healy D, Herxheimer A, Menkes DB (2006)
Antidepressants and Violence: Problems at the Interface of Medicine and Law. PLoS Med 3(9) …

This article is a clinical guide which discusses the “state-of-the-art” usage of the classic
monoamine oxidase inhibitor (MAOI) antidepressants (phenelzine, tranylcypromine, and …

A cannabis smoking trial was conducted using paid volunteers. Subjective intoxication,
measured using a visual analogue scale, was compared with heart rate and with salivary delta-9-…

This study aimed to investigate the psychological characteristics of chronic fatigue syndrome
(CFS: Holmes et al. 1988). A battery of psychometric instruments comprising the General …