Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning

AE Lyall, O Pasternak, DG Robinson, D Newell… - Molecular …, 2018 - nature.com
Free Water Imaging is a novel diffusion magnetic resonance (MR) imaging method that is
able to separate changes affecting the extracellular space from those that reflect changes in …

Characterizing white matter changes in chronic schizophrenia: A free-water imaging multi-site study

…, AE Lyall, O Pasternak, Z Kikinis, DT Newell… - Schizophrenia …, 2017 - Elsevier
Diffusion tensor imaging (DTI) studies in chronic schizophrenia have found widespread but
often inconsistent patterns of white matter abnormalities. These studies have typically used …

Childhood adversity associated with white matter alteration in the corpus callosum, corona radiata, and uncinate fasciculus of psychiatrically healthy adults

…, LKL Oestreich, AE Lyall, Z Kikinis, DT Newell… - Brain imaging and …, 2018 - Springer
Diffusion tensor imaging studies report childhood adversity (CA) is associated with reduced
fractional anisotropy (FA) in multiple white matter tracts in adults. Reduced FA may result …

[HTML][HTML] Attentional control and intelligence: MRI orbital frontal gray matter and neuropsychological correlates

…, M Niznikiewicz, JJ Levitt, DT Newell… - Behavioural …, 2015 - hindawi.com
Attentional control is a key function of working memory that is hypothesized to play an important
role in psychometric intelligence. To test the neuropsychological underpinnings of this …

Exploring the neural substrates of attentional control and human intelligence: Diffusion tensor imaging of prefrontal white matter tractography in healthy cognition

T Ohtani, PG Nestor, S Bouix, D Newell, ED Melonakos… - Neuroscience, 2017 - Elsevier
We combined diffusion tension imaging (DTI) of prefrontal white matter integrity and
neuropsychological measures to examine the functional neuroanatomy of human intelligence. …

[PDF][PDF] Clinical, social, and neuropsychological dimensions of the intersection of addiction and criminality

PG Nestor, A Woodhull, D Newell… - The journal of the …, 2018 - researchgate.net
To examine the social cognitive processes underlying the relationship of addiction and
criminality, we administered the Addiction Severity Index-CF (ASI-CF) and the Iowa Gambling …

Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition

JS Lee, CY Kim, YH Joo, D Newell, S Bouix… - Schizophrenia …, 2016 - Elsevier
Introduction Diffusion weighted MRI (dMRI) is a method sensitive to pathological changes
affecting tissue microstructure. Most dMRI studies in schizophrenia, however, have focused …

Faulty executive attention and memory interactions in schizophrenia: prefrontal gray matter volume and neuropsychological impairment

…, T Ohtani, JJ Levitt, DT Newell… - Clinical EEG and …, 2020 - journals.sagepub.com
We hypothesized that neuropsychological disturbance in schizophrenia (SZ) may reflect faulty
interactions of executive attention and episodic memory, emanating, in part, from reduced …

Dissociating prefrontal circuitry in intelligence and memory: neuropsychological correlates of magnetic resonance and diffusion tensor imaging

…, S Bouix, T Hosokawa, Y Saito, DT Newell… - Brain imaging and …, 2015 - Springer
We examined intelligence and memory in 25 healthy participants who had both prior
magnetic resonance imaging (MRI) of gray matter volumes of medial orbital frontal cortex (mOFC) …

Loosening of Associations in Chronic Schizophrenia: Intersectionality of Verbal Learning, Negative Symptoms, and Brain Structure

PG Nestor, JJ Levitt, T Ohtani, DT Newell… - Schizophrenia …, 2022 - academic.oup.com
In 1908, Bleuler proposed a unitary theory of schizophrenia, hypothesizing a “loosening of
associations” as the central mechanism underlying disturbances in thinking, motivation, and …