Until recently, the study of plasticity of neural circuits focused almost exclusively on potentiation
and depression at excitatory synapses on principal cells. Other elements in the neural …

Focal epilepsy is commonly pharmacoresistant, and resective surgery is often contraindicated
by proximity to eloquent cortex. Many patients have no effective treatment options. Gene …

The Prescribing Information System (PIS) provides an infrastructure for pharmacoepidemiology
and pharmacovigilance research, attracting growing attention due to its unique …

It has been suggested that a functional deficit in NMDA-receptors (NMDARs) on parvalbumin
(PV)-positive interneurons (PV-NMDARs) is central to the pathophysiology of schizophrenia…

Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs)
acting as the fast Ca 2+ release sensor and as the inhibitor (clamp) of spontaneous and …

Switches between global sleep and wakefulness states are believed to be dictated by top-down
influences arising from subcortical nuclei. Using forward genetics and in vivo …

Archaeology has yet to capitalise on the opportunities offered by bioarchaeological approaches
to examine the impact of the 11th-century AD Norman Conquest of England. This study …

Making accurate statements about a person's future behavior is a task rife with challenges
and pitfalls. Yet, this is precisely what is required in numerous legal and clinical settings in the …

10.7554/eLife.38346.001 Gamma-band oscillations are implicated in modulation of attention,
integration of sensory information and flexible communication among anatomically …

Key points Long‐term potentiation of glutamatergic transmission to hippocampal interneurons
in stratum oriens does not require NMDA receptors and the induction mechanisms are …