Introduction The production of model psychoses has been employed as a technique for testing
hypotheses relevant to the causes, correlates, and treatment of schizophrenia since 1921…

All model psychoses may be conceptualized as resulting from disruption in the central
processing or from interference with the normal sensory influx from body or distance receptors. …

In a previous report 7 the administration of phencyclidine hydrochloride, a chemical compound
with anesthetic and sedative properties, was shown to produce profound disturbances in …

Study of the pathological mechanisms implicated in schizophrenia has recently been accelerated
by the production of model psychoses through the use of Psychotomimetic drugs. Our …

The history of the chemical synthesis and animal/human pharmacology of phencyclidine is
documented. From its early use as a general anesthetic, chemical model of schizophrenia, …

The phenomenology of chronic anorexia nervosa is compared with that of addictive states.
A model is proposed in which brain opioids mediate the elation, neuroendocrine changes, …

The effect of sleep deprivation on behavior, thinking, motor performance, and biological
energy transfer systems was studied in a single subject who remained awake without drugs …

The endogenous plasma alkaloids codeine and morphine were shown to be elevated in
patients with anorexia nervosa and bulimia nervosa compared to control subjects. The role of …

12 paid volunteer males were kept awake for 123 hours. Attention lapses, progressive
visual changes from diplopia to illusions to hallucinations, irritability, and overt hostility were …

• The reports of patients with genital herpes suggest that it isnotan awesome physical disability;
the more distressing consequences appear to be psychosocial. The symbolic meaning of …