The treatment of schizophrenia changed drastically with the discovery of antipsychotic
medications in the 1950s, the release of clozapine in the US in 1989 and the subsequent …

People with schizophrenia commonly lack insight, that is, they are unaware of their illness
and the consequences thereof. One of the most important consequences of lack of insight is a …

In face of the multiple controversies surrounding the DSM process in general and the
development of DSM-5 in particular, we have organized a discussion around what we consider six …

Although conspiracy theories are endorsed by about half the population and occasionally
turn out to be true, they are more typically false beliefs that, by definition, have a paranoid …

In clinical practice, no clear guidelines exist to distinguish between “normal” religious
beliefs and “pathological” religious delusions. Historically, psychiatrists such as Freud have …

Background: The novel antipsychotic medications offer a more favorable extrapyramidal side
effect profile than conventional agents. It is uncertain that the novel antipsychotics have a …

To the Editor: We would like to report on the widespread “abuse” of quetiapine among
inmates in the Los Angeles County Jail—“the largest mental health institution in the world.” …

The novel antipsychotic medications, or second-generation antipsychotic medications—clozapine,
olanzapine, quetiapine, risperidone, and ziprasidone—have been gaining wide …

Background: Weight gain, and its associated complications such as the development of
diabetes, is becoming increasingly recognized as an important potential side effect of the novel …

Background: QTc interval prolongation can occur as a result of treatment with both conventional
and novel antipsychotic medications and is of clinical concern because of its association …