• Frontal lobe dysfunction is widely suspected to underlie negative symptoms of schizophrenia.
This hypothesis is based largely on long-standing observations of the similarities …

OBJECTIVES Functional MRI (fMRI) holds the promise of non-invasive mapping of human
brain function in both health and disease. Yet its sensitivity and reliability for mapping higher …

Bilateral decreases in striatal%-raclopride binding were observed in adult female baboons
with high resolution PET following administration of drugs that act centrally on dopaminergic …

METHOD The subjects were 10 male schizophrenic inpatients aged 18 to 49 years who met
the DSM-III criteria and Research Diagnostic Criteria for chronic schizophrenia with either …

Subanesthetic doses of the noncompetitive N-methyl-D-aspartate (NMDA) antagonist
ketamine exacerbate psychosis in schizophrenic patients, and ketamine has significant abuse …

Positron emission tomography and in vivo microdialysis were used to study serotonin's role
in modulating striatal dopamine. Serial PET studies were performed in adult female baboons …

… NELSON, J., and BRODIE, JD 1990. Comparison of a random search algorithm and mixed
… NELSON, J., et BRODIE, JD 1990. Comparison of a random search algorithm and mixed …

Extensive neuroanatomical, neurophysiological, and behavioral evidence demonstrates
that GABAergic neurons inhibit endogenous dopamine release in the mammalian corpus …

Cocaine's addictive liability has been linked to its pharmacologic actions on mesotelencephalic
dopamine (DA) reinforcement/reward pathways in the central nervous system (CNS). …

Local cerebral metabolic rates were determined by positron emission tomography and the
deoxyglucose method in a group of 10 chronic schizophrenic subjects before and after …