The clinical and pathological differences between synucleinopathies such as Parkinson’s
disease and multiple system atrophy have been postulated to stem from unique strains of α-…

Prions are proteins that adopt alternative conformations that become self-propagating; the
PrP Sc prion causes the rare human disorder Creutzfeldt–Jakob disease (CJD). We report …

Prions are proteins that adopt alternative conformations, which become self-propagating.
Increasing evidence argues that prions feature in the synucleinopathies that include Parkinson’…

The essential role of the cellular prion protein (PrP C ) in prion disorders such as Creutzfeldt–Jakob
disease is well documented. Moreover, evidence is accumulating that PrP C may act …

The aggregation and deposition of amyloid-β (Aβ) peptides are believed to be central
events in the pathogenesis of Alzheimer’s disease (AD). Inoculation of brain homogenates …

An increasing number of studies argues that self-propagating protein conformations (ie,
prions) feature in the pathogenesis of several common neurodegenerative diseases. Mounting …

Increasingly, evidence argues that many neurodegenerative diseases, including progressive
supranuclear palsy (PSP), are caused by prions, which are alternatively folded proteins …

An increasing number of studies continue to show that the amyloid β (Aβ) peptide adopts an
alternative conformation and acquires transmissibility; hence, it becomes a prion. Here, we …

Despite intense research efforts, the physiological function and molecular environment of
the amyloid precursor protein has remained enigmatic. Here we describe the application of …

In recent years, a new generation of animal models of Parkinson's disease (PD) based on
ectopic expression, overexpression, or intracerebral injection of the protein α-synuclein have …