Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will
require the translation of proof-of-principle concepts into a scalable, controlled, and …

Type 1 diabetes (T1D) affects approximately 1.25 million people in the US alone and is
deadly if not managed with insulin injections. This paper describes the production of insulin-…

Skeletal muscle is one of a several adult post-mitotic tissues that retain the capacity to
regenerate. This relies on a population of quiescent precursors, termed satellite cells. Here we …

Although the extremely thermophilic archaea (T opt ≥ 70C) may be the most primitive
extant forms of life, they have been studied to a limited extent relative to mesophilic …

Primary failure of host defense mechanisms has been associated with increased infection
and mortality. Anergy, the failure of delayed hypersensitivity response, has been shown to …

Background. Patients with recurrent Clostridium difficile infection (CDI) have a ≥60% risk of
relapse, as conventional therapies do not address the underlying gastrointestinal dysbiosis. …

Despite the wide administration of several effective vaccines, rotavirus (RV) remains the
single most important etiological agent of severe diarrhea in infants and young children …

Background Nurses comprise the largest component of the health workforce worldwide and
numerous models of workforce allocation and profile have been implemented. These …

Thermophilic microorganisms are attractive candidates for conversion of lignocellulose to
biofuels because they produce robust, effective, carbohydrate-degrading enzymes and survive …

Background Irbesartan, a long acting selective angiotensin-1 receptor inhibitor, in Marfan
syndrome might reduce aortic dilatation, which is associated with dissection and rupture. We …