Mitochondria are intracellular organelles crucial to the production cellular energy. Mitochondrial
disease results from a malfunction in this biochemical cascade. These disorders can …

The Alzheimer's Association's Research Roundtable met in November 2016 to explore how
best to measure changes in cognition and function in the preclinical stage of Alzheimer's …

… Author links open overlay panel Allen D Roses 1 2 , Ann M Saunders 2 , Michael W Lutz 2
, Nanyin Zhang 3 , Ahmad R Hariri 2 , Karen E Asin 4 , Donna G Crenshaw 1 , Kumar Budur 4 …

Background Progressive supranuclear palsy is a neurodegenerative disorder associated with
tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to …

Substance abuse is a major public health problem with high morbidity and mortality. Comorbid
disorders are suspected to cause a high relapse rate. Subjects with sleep disorders tend …

Tau accumulation in patients with Alzheimer’s disease tracks closely with cognitive decline
and plays a role in the later stages of disease progression. This phase 2 study evaluated the …

The study of Alzheimer's disease (AD) has led to an increased understanding of the multiple
pathologies and pathways of the disease. As such, it has been proposed that AD and its …

Introduction Foslevodopa/foscarbidopa, a soluble formulation of levodopa/carbidopa (LD/CD)
prodrugs for the treatment of Parkinson’s disease (PD), is administered as a 24-hour/day …

Background Levodopa is the most effective symptomatic therapy for Parkinson's disease,
but patients with advanced Parkinson's disease develop motor fluctuations with chronic oral …

Objective. Major depressive disorder is associated with sleep disturbances. An
electroencephalographic pattern of alpha wave intrusion in delta wave sleep (alpha-delta sleep) is …