During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's
biochemical dissection of β-amyloid in 1984, the "amyloid hypothesis" of Alzheimer's disease has …

Three decades of genetic research in Alzheimer disease (AD) have substantially broadened
our understanding of the pathogenetic mechanisms leading to neurodegeneration and …

We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …

The past decade has witnessed hundreds of reports declaring or refuting genetic association
with putative Alzheimer disease susceptibility genes. This wealth of information has …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

Objective: To use fMRI to investigate whether hippocampal and entorhinal activation during
learning is altered in the earliest phase of mild cognitive impairment (MCI). Methods: Three …

In an effort to pinpoint potential genetic risk factors for schizophrenia, research groups worldwide
have published over 1,000 genetic association studies with largely inconsistent results. …

Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase
cleavage fragments represents an early pathological change in brains of Huntington's disease …

The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early
successes in identifying three genes that cause early-onset familial AD (those that encode …