Pruritus is often the most troublesome symptom in patients with chronic liver disease,
particularly when cholestasis is a prominent feature. The exact pathogenesis is unknown, but …

Each individual is provided with a unique gut microbiota profile that plays many specific
functions in host nutrient metabolism, maintenance of structural integrity of the gut mucosal …

Systemic treatment of renal cancer (RCC) has undergone remarkable changes over the
past 20 years with the introduction of immunotherapeutic agents targeting programmed cell …

Methylmercury is a potent toxic present in Amazonian fish species due to gold mining activities.
In the present work, we investigated the morphological effects of methylmercury in liver …

Hematological indices are gaining general acceptance as valuable tools in monitoring
various aspects the health of fish exposed to contaminants. In this work some effects of methyl …

Salivary gland carcinomas (SGCs) are rare tumors encompassing a wide spectrum of
histologic/biologic entities. Standard non-surgical treatments are ineffective in case of advanced …

Background & Aims Cumulating evidence underlines the crucial role of aberrant lipogenesis
in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential …

… Muscle and brain samples were homogenized in phosphate buffer (0.1 M, pH 7.5), and
centrifuged at ~10,000×g … M. Mela acknowledges a post-doctoral fellowship from CNPq/INCT-TA. …

More than a quarter of the world's carnivores are threatened, often due to multiple and complex
causes. Considerable research efforts are devoted to resolving the mechanisms behind …

Activation of the AKT/mTOR cascade and overexpression of c-Met have been implicated in
the development of human hepatocellular carcinoma (HCC). To elucidate the functional …