… Michael Welner, MD, is a forensic psychiatrist and clinical … Welner pioneered efforts to
standardize the classification of … Welner’s other published research areas have included drug …

Introduction activation of the RXR gene resulted in embryonal death as a consequence of
cardiac hypoplasia be-Mouse embryonic stem (ES) cells have been shown to differentiate into …

Background— Hypertensive target organ damage, especially cardiac hypertrophy with heart
failure and arrhythmia, is a major source of morbidity and mortality. Angiotensin II, a major …

The recently cloned (pro)renin receptor [(P)RR] mediates renin-stimulated cellular effects by
activating mitogen-activated protein kinases and promotes nonproteolytic prorenin activation…

We tested the hypothesis that the renin inhibitor aliskiren ameliorates organ damage in rats
transgenic for human renin and angiotensinogen genes (double transgenic rat [dTGR]). Six-…

The concept of endothelium‐derived relaxing factor (EDRF) put forward in 1980 by Furchgott
and Zawadzki implies that nitric oxide (NO) produced by NO synthase (NOS) in the …

… Apparent K m and V max values of the recombinant Cyp4a enzymes were calculated using
… 76 nmol·nmol −1 ·min −1 and apparent K m values between 2 and 16 μM (Table 1). Addition …

Megalin is an endocytic receptor highly expressed in the proximal tubules of the kidney.
Recently, we demonstrated that this receptor is essential for the renal uptake and conversion of …

Nuclear factor kappa B (NF-κB) participates in hypertension-induced vascular and target-organ
damage. We tested whether or not endothelial cell–specific NF-κB suppression would be …

Antineutrophil cytoplasmic antibodies (ANCAs) with specificity for proteinase 3 (PR3) are
central to a form of ANCA-associated vasculitis. Membrane PR3 (mPR3) is expressed only on a …