Severe liver disease in pregnancy is rare. Pregnancy-related liver disease is the most frequent
cause of liver dysfunction in pregnancy and provides a real threat to fetal and maternal …

Autoimmune hepatitis is a disease of the hepatic parenchyma that can present in acute or
chronic forms. In common with many autoimmune diseases, autoimmune hepatitis is …

Twin studies are powerful tools to discriminate whether a complex disease is due to genetic
or environmental factors. High concordance rates among monozygotic (MZ) twins support …

Importance Familial amyloid polyneuropathy, a lethal genetic disease caused by aggregation
of variant transthyretin, induces progressive peripheral nerve deficits and disability. …

In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have
been identified in recent genome-wide association studies (GWAS). To identify additional loci, …

Objective. —To assess the safety and efficacy of optic nerve decompression surgery
compared with careful follow-up alone in patients with nonarteritic anterior ischemic optic …

Background Primary biliary cholangitis is a rare, chronic cholestatic liver disease characterized
by the destruction of interlobular bile ducts, leading to cholestasis and liver fibrosis. …

BACKGROUND, & AIMS: Studies of primary biliary cirrhosis (PBC) phenotypes largely have
been performed using small and selected populations. Study size has precluded …

The biochemical response to ursodeoxycholic acid (UDCA)—so‐called “treatment response”—strongly
predicts long‐term outcome in primary biliary cholangitis (PBC). Several long‐…

We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium
and 8,514 UK population controls across 196,524 variants within 186 known autoimmune risk …