Key concepts in genetic epidemiology
This article is the first in a series of seven that will provide an overview of central concepts
and topical issues in modern genetic epidemiology. In this article, we provide an overall …
and topical issues in modern genetic epidemiology. In this article, we provide an overall …
Genetic epidemiology and public health: hope, hype, and future prospects
Genetic epidemiology is a rapidly expanding research field, but the implications of findings
from such studies for individual or population health are unclear. The use of molecular …
from such studies for individual or population health are unclear. The use of molecular …
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
…, SM Brand, JA Staessen, TJ Wang, PR Burton… - Nature, 2011 - nature.com
Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …
Genome-wide association study identifies eight loci associated with blood pressure
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …
To date, identification of common genetic variants influencing blood pressure has proven …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
…, JA Todd, D Easton, DG Clayton, PR Burton… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility
to more common diseases than any other region of the human genome, including almost …
to more common diseases than any other region of the human genome, including almost …
Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study
…, LI Landau, FJ Stanley, GE Kendall, PR Burton - Bmj, 1999 - bmj.com
Objectives: To investigate the association between the duration of exclusive breast feeding
and the development of asthma related outcomes in children at age 6 years. Design: …
and the development of asthma related outcomes in children at age 6 years. Design: …
Intrapartum risk factors for newborn encephalopathy: the Western Australian case-control study
…, JM Keogh, LM Alessandri, F O'Sullivan, PR Burton… - Bmj, 1998 - bmj.com
… Paul R Burton, senior biostatisticianc, … Badawi N, Kurinczuk JJ, Keogh JM, Alessandri
LM, O'Sullivan F, Burton PR et al. … Articles by Paul R Burton …
LM, O'Sullivan F, Burton PR et al. … Articles by Paul R Burton …
Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study
…, JM Keogh, LM Alessandri, F O'Sullivan, PR Burton… - Bmj, 1998 - bmj.com
… Paul R Burton, senior biostatisticianc, … Badawi N, Kurinczuk JJ, Keogh JM, Alessandri
LM, O'Sullivan F, Burton PR et al. … Articles by Paul R Burton …
LM, O'Sullivan F, Burton PR et al. … Articles by Paul R Burton …
Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure
…, NA Sheehan, KJ Scurrah, PR Burton - Statistics in …, 2005 - Wiley Online Library
A population‐based study of a quantitative trait may be seriously compromised when the trait
is subject to the effects of a treatment. For example, in a typical study of quantitative blood …
is subject to the effects of a treatment. For example, in a typical study of quantitative blood …