Telomerase is a cellular reverse transcriptase that helps to provide genomic stability in
highly proliferative normal, immortal, and tumor cells by maintaining the integrity of the …

… Certain stem cells or germline populations are telomerase positive (13, 27, 28) and have
long or indefinite life-spans, illustrating that telomerase expression per se is not oncogenic. …

While there has been substantial experimental evidence in support of the telomere-telomerase
hypothesis of aging and cancer, it has been suggested that the theory has been …

The maintenance of chromosome termini, or telomeres, requires the action of the enzyme
telomerase, as conventional DNA poly-merases cannot fully replicate the ends of linear …

The ectopic expression of telomerase 1, 2 in normal human cells results in an extended
lifespan 3, 4, indicating that telomere shortening regulates the timing of cellular senescence. As …

Most normal human diploid cells have no detectable telomerase; however, expression of the
catalytic subunit of telomerase is sufficient to induce telomerase activity and, in many cases, …

The ends of vertebrate chromosomes are composed of large tracts of a repeated sequence,
TTAGGG, which are known as telomeres. Normal somatic cells progressively lose telomeric …

Telomerase is a ribonucleoprotein whose activity has been detected in germ line cells, immortal
cells, and most cancer cells. Except in stem cells, which have a low level of telomerase …

The ribonucleoprotein telomerase holoenzyme is minimally composed of a catalytic subunit,
hTERT, and its associated template RNA component, hTR. We have previously found two …

… Support of research in the laboratories of Gewirtz, Holt and Elmore has been provided by
the NIH, Department of Defense and American Institute for Cancer Research. We are grateful …