Charting a course for genomic medicine from base pairs to bedside
, … Institute Overall leadership Green Eric D. Guyer Mark … - Nature, 2011 - nature.com
There has been much progress in genomics in the ten years since a draft sequence of the
human genome was published. Opportunities for understanding health and disease are now …
human genome was published. Opportunities for understanding health and disease are now …
The international HapMap project
…, FS Collins, LD Brooks, JE McEwen, MS Guyer… - 2003 - deepblue.lib.umich.edu
The goal of the International HapMap Project is to determine the common patterns of DNA
sequence variation in the human genome and to make this information freely available in the …
sequence variation in the human genome and to make this information freely available in the …
[HTML][HTML] The genotype-tissue expression (GTEx) project
…, G Temple, S Volpi, JT Boyer, EJ Thomson, MS Guyer… - Nature …, 2013 - nature.com
Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …
but, for the majority of these, the mechanisms underlying disease susceptibility remain …
Genome sequence of the Brown Norway rat yields insights into mammalian evolution
…, J Peterson, M Guyer… - Nature, 2004 - nature.com
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and
drug development, having made inestimable contributions to human health. We report here …
drug development, having made inestimable contributions to human health. We report here …
The ENCODE (ENCyclopedia of DNA elements) project
EA Feingold, PJ Good, MS Guyer, S Kamholz… - Science, 2004 - scholarworks.bwise.kr
The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements
in the human genome sequence. The pilot phase of the Project is focused on a specified …
in the human genome sequence. The pilot phase of the Project is focused on a specified …
The NIH human microbiome project
…, P Starke-Reed, S Zakhari, B Watson, M Guyer… - Genome …, 2009 - genome.cshlp.org
The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for
Biomedical Research ( http://nihroadmap.nih.gov ), is a multi-component community resource. …
Biomedical Research ( http://nihroadmap.nih.gov ), is a multi-component community resource. …
[HTML][HTML] A vision for the future of genomics research
FS Collins, ED Green, AE Guttmacher, MS Guyer… - nature, 2003 - nature.com
… Guyer … To view a larger version of this image download the pdf (1.9 M). … Avery, OT,
MacLeod, CM & McCarty, M. Studies of the chemical nature of the substance inducing …
MacLeod, CM & McCarty, M. Studies of the chemical nature of the substance inducing …
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
…, KH Wan, L Yang, C Yu, E Feingold, P Good, M Guyer… - Science, 2010 - science.org
To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …
Variations on a theme: cataloging human DNA sequence variation
FS Collins, MS Guyer, A Chakravarti - Science, 1997 - science.org
Genetic factors contribute to virtually every human disease, conferring susceptibility or
resistance, or influencing interaction with environmental factors. Much research in both the public …
resistance, or influencing interaction with environmental factors. Much research in both the public …
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
…, PJ Good, P Green, F Gullier, M Gutwein, MS Guyer… - Science, 2010 - science.org
We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …
nematode Caenorhabditis elegans, a key model organism. These data sets include …