RT Journal Article SR Electronic T1 Commentary: Intoxication and Settled Insanity—Unsettled Matters JF Journal of the American Academy of Psychiatry and the Law Online JO J Am Acad Psychiatry Law FD American Academy of Psychiatry and the Law SP 183 OP 187 VO 35 IS 2 A1 Gregory B. Leong A1 Sarah E. Leisenring A1 Margaret D. Dean YR 2007 UL http://jaapl.org/content/35/2/183.abstract AB The role of exogenous substances in the genesis of mental symptoms has found relevance in some jurisdictions when a defense of settled insanity is raised. However, the current nosology and knowledge base reveal ambiguity and unresolved questions about the present science related to settled insanity.