RT Journal Article SR Electronic T1 Psychiatric Side Effects of Mefloquine: Applications to Forensic Psychiatry JF Journal of the American Academy of Psychiatry and the Law Online JO J Am Acad Psychiatry Law FD American Academy of Psychiatry and the Law SP 224 OP 235 VO 41 IS 2 A1 Ritchie, Elspeth Cameron A1 Block, Jerald A1 Nevin, Remington Lee YR 2013 UL http://jaapl.org/content/41/2/224.abstract AB Mefloquine (previously marketed in the United States as LariamĀ®) is an antimalarial medication with potent psychotropic potential. Severe psychiatric side effects due to mefloquine intoxication are well documented, including anxiety, panic attacks, paranoia, persecutory delusions, dissociative psychosis, and anterograde amnesia. Exposure to the drug has been associated with acts of violence and suicide. In this article, we discuss the history of mefloquine use and describe plausible mechanisms of its psychotropic action. Mefloquine intoxication has not yet been successfully advanced in legal proceedings as a defense or as a mitigating factor, but it appears likely that it eventually will be. Considerations for the application of claims of mefloquine intoxication in forensic settings are discussed.