Ethanol metabolism in heavy drinkers after massive and moderate alcohol intake
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Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework
2010, Forensic Science InternationalCitation Excerpt :The minimum and maximum values spanned from 12.6 to 38.0 mg/100 mL/h as determined during detoxification, which should not be confused with elimination rates in sober alcoholics. The rate of alcohol elimination was determined during detoxification and once again after the subjects had been alcohol-free for a few days [39]. During the second exposure to alcohol rates of elimination from blood were similar to those seen in moderate drinkers because CYP2E1 is no longer induced, because of a re-synthesis of enzyme protein during the few days of alcohol abstinence.
Interference of ethanol and methylmercury in the developing central nervous system
2009, NeuroToxicologyAcute exposure to the nutritional toxin alcohol reduces brain protein synthesis in vivo
2003, Metabolism: Clinical and ExperimentalCitation Excerpt :Second, the blood levels of ethanol (i.e., 50 to 60 mmol/L62) achieved with this dosing regimen (75 mmol/kg body weight) are similar to levels occurring in pathophysiologic situations. For example, clinical studies have reported levels of 40 to 60 mmol/L,63 76 to 111 mmol/L,64 and 38 to 100 mmol/L.65 With respect to the intraperitoneal route of alcohol dosage, we are aware that other techniques of administration can be used in acute ethanol-dosing studies, such as the intravenous or intragastric routes.66 However, intraperitoneal dosing as used in the present study, ensures greater bioavailability of alcohol.
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