Original articleGeneralized and Specific Neurocognitive Deficits in Prodromal Schizophrenia
Section snippets
Subjects
Clinical high-risk patients were recruited for research from referrals to the clinical arm of the Recognition and Prevention (RAP) Program (the RAP Clinic). Written, informed consent was obtained from the patient if >17 years old or from the parent (with patient’s written assent) if under 18 years. The research protocol was approved by the Institutional Review Board at North Shore-Long Island Jewish Health System (NS-LIJHS) and potential subjects were informed that treatment in the RAP Clinic
Baseline Between-Group Comparisons: Estimated Premorbid and Current IQ
Compared with CNTL, RAP patients had significantly lower estimated premorbid IQ [t(73) = 2.17, p = .033] and estimated current full-scale IQ [t(74) = 3.99, p < .001]. Deficits in current IQ remained statistically significant even after controlling for premorbid IQ and test form in ANCOVA [F(1,69) = 9.97, p = .002]. Repeated measures analysis of variance demonstrated a significant group by measure interaction [F(1,70) = 4.08, p = .047]. As shown in Figure 1, CNTL subjects showed a slight
Discussion
There are several significant findings of this study, which will be discussed in turn. First, clinical high-risk subjects showed significant deficits relative to control subjects in both estimated premorbid and current IQ. Moreover, RAP patients had lower current estimated IQ (∼1.0 SD reduction) than was predicted by premorbid estimated IQ (∼.5 SD). This pattern of deficits, identified in adolescent patients who were not yet psychotic, is consistent with a progressive neurodevelopmental model
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