This report documents the adjustment to prison life by individuals with schizophrenia and compares their adaptation with a control group with no known mental illness matched for age, race, sex, most serious crime, and security level. On all outcome variables, number of infractions, number of "lock-ups", days in "lock-up," ability to obtain a job in prison, and ability to obtain release from prison, the group with schizophrenia was inferior to the control group. That inmates with schizophrenia may require special assistance in prison and the need for future investigation are discussed.