Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

Ibudilast, a neuroimmune modulator which selectively inhibits phosphodiesterases (PDE)-3,
-4, -10, and -11, and macrophage migration inhibitory factor (MIF), shows promise as a …

Background: Alcohol use disorder (AUD) and its associated consequences remain significant
public health concerns. Given that AUD represents a spectrum of severity, treatment …

Rationale Screening novel medications for alcohol use disorder (AUD) requires models that
are both efficient and ecologically-valid. Ideally, such models would be associated with the …

In 2013, juvenile courts nationwide processed 1,058,500 cases. Of the youth processed in
juvenile court, 76% were male and 24% were female. Sixty-two percent were white, 35% were …

Human laboratory models have been used in medication development for alcohol use disorder
(AUD) for decades. Paradigms such as alcohol cue-exposure and alcohol administration …

There are an estimated 60,000 evaluations annually for competence to stand trial for felony
indictments and likely more for misdemeanor indictments. Thus, there is an increasing …

Mr. M, age 45, is found naked outside his apartment. He has a history of schizophrenia,
paranoid type, hypertension, and diet-controlled type 2 diabetes mellitus. His schizophrenia has …

INFORMATION TO USERS Page 1 INFORMATION TO USERS This manuscript has been
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