Over the past 50 years, steady growth in the field of metalloproteinase biology has shown
that the degradation of extracellular matrix components represents only a fraction of the …

Metabolism of haem by-products such as bilirubin by humans and their gut microbiota is
essential to human health, as excess serum bilirubin can cause jaundice and even neurological …

Hematopoietic stem cells (HSCs) self-renew or differentiate into blood cell lineages following
extrinsic cues propagated in specialized niches. Support cells and soluble factors in the …

Timp3 is commonly silenced in breast cancer, but mechanistic studies have identified both
tumor promotion and suppression effects of this gene. We have taken a genetic approach to …

Regulated growth plate activity is essential for postnatal bone development and body stature,
yet the systems regulating epiphyseal fusion are poorly understood. Here, we show that …

Epilepsy is a common diagnosis and can quickly progress to status epilepticus which
requires rapid treatment. Levetiracetam is a frequent treatment choice in these situations. The …

Objective:This brief report analyzes a first-episode psychosis (FEP) clinic’s shift from in-person
treatment to the provision of services through telemental health during the 2019 …

Deregulated proteolysis invariably underlies most human diseases including bone pathologies.
Metalloproteinases constitute the largest of the five protease families, and the metzincin …

Study objective The objective of this study was to evaluate clinical outcomes associated
with time to administration and dose of four‐factor prothrombin complex concentrate (4F‐PCC) …

The human gut is home to trillions of microorganisms that are responsible for the modification
of many orally administered drugs, leading to a wide range of therapeutic outcomes. …