Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9-R-(2-Phosphonomethoxypropyl …
BL Robbins, RV Srinivas, C Kim… - Antimicrobial agents …, 1998 - Am Soc Microbiol
Bis(isopropyloxymethylcarbonyl) 9-R-(2-phosphonomethoxypropyl)adenine [bis(POC)PMPA]
has been identified as a novel prodrug of PMPA. The anti-human immunodeficiency virus …
has been identified as a novel prodrug of PMPA. The anti-human immunodeficiency virus …
Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl) adenine in human lymphoid cells
BL Robbins, J Greenhaw, MC Connelly… - Antimicrobial agents …, 1995 - Am Soc Microbiol
9-(2-Phosphonylmethoxyethyl)adenine (PMEA), the acyclic phosphonate analog of adenine
monophosphate, is a promising antiviral drug with activity against herpesviruses, Epstein-…
monophosphate, is a promising antiviral drug with activity against herpesviruses, Epstein-…
Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl) cytosine (HPMPC) in vero cells
MC Connelly, BL Robbins, A Fridland - Biochemical pharmacology, 1993 - Elsevier
The cellular uptake of phosphonylmethoxypropyl cytosine (HPMPC) was characterized to
gain insight into the molecular properties that allow this anticytomegalovirus drug to permeate …
gain insight into the molecular properties that allow this anticytomegalovirus drug to permeate …
Rationalisation of the relationship between proton leakage and water flux through anion exchange membranes
BJ Robbins, RW Field, ST Kolaczkowski… - Journal of membrane …, 1996 - Elsevier
Electromembrane concentration of nitric acid using anion exchange membranes has been
studied in a laboratory pilot rig. The main factor limiting acid concentration has previously …
studied in a laboratory pilot rig. The main factor limiting acid concentration has previously …
Simultaneous measurement of intracellular triphosphate metabolites of zidovudine, lamivudine and abacavir (carbovir) in human peripheral blood mononuclear cells …
BL Robbins, PA Poston, EF Neal, C Slaughter… - … of Chromatography B, 2007 - Elsevier
All nucleoside reverse transcriptase inhibitors (NRTI) must first be metabolized to their
triphosphate forms in order to be active against HIV. Zidovudine (ZDV), abacavir (ABC) and …
triphosphate forms in order to be active against HIV. Zidovudine (ZDV), abacavir (ABC) and …
Determination of the rifamycin antibiotics rifabutin, rifampin, rifapentine and their major metabolites in human plasma via simultaneous extraction coupled with LC/MS …
…, AT Podany, JS Baldwin, BL Robbins… - … of pharmaceutical and …, 2015 - Elsevier
A novel assay using high pressure liquid chromatography (HPLC) coupled to mass
spectrometer (MS) detection was developed and validated for the rifamycin anti-tuberculosis …
spectrometer (MS) detection was developed and validated for the rifamycin anti-tuberculosis …
Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells
BL Robbins, CK Wilcox, A Fridland… - … : The Journal of …, 2003 - Wiley Online Library
Objective. As tenofovir disoproxil fumarate substantially increases plasma concentrations of
didanosine in patients with human immunodeficiency virus‐1 infection, we sought to …
didanosine in patients with human immunodeficiency virus‐1 infection, we sought to …
Long-term outcomes for HIV-infected infants less than 6 months of age at initiation of lopinavir/ritonavir combination antiretroviral therapy
…, MD Hughes, R Hazra, JA Pinto, BL Robbins… - Aids, 2011 - journals.lww.com
Objective: To investigate the longitudinal pharmacokinetics, safety and efficacy of lopinavir/ritonavir
(LPV/r) in HIV-infected infants initiating combination antiretroviral therapy (cART) …
(LPV/r) in HIV-infected infants initiating combination antiretroviral therapy (cART) …
Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus …
BL Robbins, EV Capparelli, EG Chadwick… - Antimicrobial agents …, 2008 - Am Soc Microbiol
Human immunodeficiency virus (HIV)-infected children and adolescents who are failing
antiretrovirals may have a better virologic response when drug exposures are increased, using …
antiretrovirals may have a better virologic response when drug exposures are increased, using …
Quantification of cell-associated atazanavir, darunavir, lopinavir, ritonavir, and efavirenz concentrations in human mononuclear cell extracts
AT Podany, LC Winchester, BL Robbins… - Antimicrobial agents …, 2014 - Am Soc Microbiol
An ultrasensitive assay utilizing high-pressure liquid chromatography and mass spectrometry
detection was developed and validated for the quantification of the antiretrovirals …
detection was developed and validated for the quantification of the antiretrovirals …