In the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors, the T315I
gatekeeper mutant has emerged as resistant to all currently approved agents. This report …

… Citation: Chen I, Clarke SE, Gosling R, Hamainza B, Killeen G, Magill A, et al. (2016) “Asymptomatic”
Malaria: A Chronic and Debilitating Infection That Should Be Treated. PLoS Med 13(1) …

50 years after a noble but flawed attempt to eradicate malaria in the mid-20th century, the
global malaria community is once again seriously considering eradication. Momentum towards …

Mass drug administration (MDA) was a component of many malaria programs during the
eradication era, but later was seldomly deployed due to concerns regarding efficacy and …

10.7554/eLife.34463.001 Understanding the importance of gametocyte density on human-to-mosquito
transmission is of immediate relevance to malaria control. Previous work (…

Background Single low doses of primaquine, when added to artemisinin-based combination
therapy, might prevent transmission of Plasmodium falciparum malaria to mosquitoes. We …

Background Primaquine and methylene blue are gametocytocidal compounds that could
prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the efficacy …

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in
falciparum malaria include measurement of the duration of gametocytaemia, the rate of …

Purpose Appendiceal neoplasms are heterogeneous and are often treated with
chemotherapy similarly to colorectal cancer (CRC). Genomic profiling was performed on 703 …

Background Single low-dose primaquine (PQ) reduces Plasmodium falciparum infectivity
before it impacts gametocyte density. Here, we examined the effect of PQ on gametocyte sex …