Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

…, C Adams, D Patterson, LE Adler… - Proceedings of the …, 1997 - National Acad Sciences
Inheritance of a defect in a neuronal mechanism that regulates response to auditory stimuli
was studied in nine families with multiple cases of schizophrenia. The defect, a decrease in …

Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.

LE Adler, E Pachtman, RD Franks, M Pecevich… - Biological …, 1982 - europepmc.org
The action of CNS inhibitory neuronal mechanisms was tested in acutely psychotic
unmedicated schizophrenic patients and in normal controls. An early positive component of the …

Schizophrenia, sensory gating, and nicotinic receptors

LE Adler, A Olincy, M Waldo, JG Harris… - Schizophrenia …, 1998 - academic.oup.com
A series of human and animal investigations has suggested that altered expression and
function of the α7-nicotinic cholinergic receptor may be responsible for the auditory sensory …

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

R Freedman, M Hall, LE Adler, S Leonard - Biological psychiatry, 1995 - Elsevier
This study tests the hypothesis that nicotinic cholinergic receptors, including those sensitive
to the antagonist α-bungarotoxin, are decreased in the hippocampus of schizophrenics. The …

Normalization of auditory physiology by cigarette smoking in schizophrenic patients.

LE Adler, LD Hoffer, A Wiser… - The American journal of …, 1993 - europepmc.org
Objective Because many schizophrenic patients are heavy smokers, it has been suggested
that nicotine normalizes some neuronal deficit involved in their illness. Schizophrenic …

Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report

…, B Hitsman, JC Beckham, M Zvolensky, LE Adler… - 2008 - academic.oup.com
The National Institute of Mental Health (NIMH) convened a meeting in September 2005 to
review tobacco use and dependence and smoking cessation among those with mental …

Proof-of-concept trial of an α7 nicotinic agonist in schizophrenia

…, JO Stevens, L Martin, LE Adler… - Archives of general …, 2006 - jamanetwork.com
Context The α7 nicotinic acetylcholine receptor gene,CHRNA7, is associated with genetic
transmission of schizophrenia and related cognitive and neurophysiological sensory gating …

[PDF][PDF] The emotional cycle of deployment: A military family perspective

…, R House, J Christenson, LE Adler - US Army Medical …, 2001 - west-point.org
… One challenge, during this stage, is the rapid speed of information provided by widespread
phone and e-mail access. In the near future, one can even expect that individual soldiers will …

Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients.

R Freedman, LE Adler, MC Waldo, E Pachtman… - Biological …, 1983 - europepmc.org
Central nervous system inhibitory neuronal mechanisms were assessed in clinically stable
chronic schizophrenic patients treated with neuroleptic drugs to provide data for comparison …

Association of promoter variants in the α7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia

…, G Zerbe, A Olincy, RG Ross, LE Adler… - Archives of general …, 2002 - jamanetwork.com
Background The α7 neuronal nicotinic acetylcholine receptor subunit gene(CHRNA7) has
been implicated as a candidate gene for schizophrenia, and for an auditory sensory …