Importance The association between red blood cell (RBC) transfusion strategies and health
care–associated infection is not fully understood. Objective To evaluate whether RBC …

Transfusion-related acute lung injury (TRALI) is a form of posttransfusion acute pulmonary
insufficiency that has been linked to the infusion of biologic response modifiers (BRMs), …

Background Anemia is frequent in patients with cancer, but there are concerns regarding
treatment with erythropoiesis-stimulating agents. Blood transfusions are commonly used as an …

Fibroblasts represent a dynamic population of cells, exhibiting functional heterogeneity within
and among tissues. Fibroblast heterogeneity also results from phenotypic differences and …

The paradigm related to the immunologic consequences of allogeneic blood transfusions
has been extended from humoral allosensitization to the effects of transfusion on cellular …

Background— The rate of hospitalization for venous thromboembolism (VTE) is increasing in
the United States. Although predictors of hospital-acquired VTE are well-known, triggers of …

Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma
patients in whom both systemic inflammation and immune suppression are associated with …

Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor
important in lipid metabolism, diabetes, and inflammation. We evaluated whether human …

BACKGROUND: Cardiopulmonary adverse events after transfusion include transfusion‐related
acute lung injury (TRALI) and transfusion‐associated circulatory overload (TACO), which …

Background Transfusion practices in hospitalised patients are being re-evaluated, in part
due to studies indicating adverse effects in patients receiving large quantities of stored blood. …