Breast cancer is the most prevalent cancer in women, and over two-thirds of cases express
estrogen receptor-α (ER-α, encoded by ESR1). Through a prospective clinical sequencing …

Individual cancers harbor a set of genetic aberrations that can be informative for identifying
rational therapies currently available or in clinical trials. We implemented a pilot study to …

BACKGROUND: Recent medical, demographic, and social trends might have had an
important impact on the cognitive health of older adults. To assess the impact of these multiple …

The authors argue that informed consent is ethically necessary in pragmatic trials that
randomly assign individual patients to treatments, even when treatment options are within the …

“Deliberative democracy” is an increasingly popular method for soliciting public input on
health care policies. There are a number of ways of organizing deliberative democracy (DD) …

Elite suppressors are untreated individuals with human immunodeficiency virus type 1 (HIV-1)
infection who maintain viral loads <50 copies/mL. Using a single-copy assay, we show …

… The Editors'summary of the article on abdominal aortic aneurysm screening by Kim and
colleagues is dangerously misleading. It says, in part, "The 7-year follow-up report of a large …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Breast cancer is the most common invasive cancer in women, affecting more than 10% of
women worldwide. Microscopic analysis of a biopsy remains one of the most important …

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels. …