Benzodiazepines and medications acting on benzodiazepine receptors that do not have a
benzodiazepine structure (z-drugs) have been viewed by some experts and regulatory bodies …

Psychotic depression was initially considered to be at one end of a continuum of severity of
major depression. Subsequent experience demonstrated that psychosis is an independent …

The authors measured intracellular Ca2+ concentrations in four manic and five bipolar
depressed patients and seven comparison subjects. Platelet and lymphocyte intracellular Ca2+ …

• Using the fluorescent indicator Fura 2, we measured the free intracellular calcium ion
concentration in blood platelets of patients with untreated mania, bipolar depression, and …

Mood disorders can be relatively straightforward or they can assume complex forms that are
difficult to treat. In this chapter, we review the epidemiology, diagnosis, comorbidity, …

Consistent with previous studies, elevated free intracellular calcium ion concentrations ([Ca
2+ ] i ) were found in blood platelets and lymphocytes of patients with mania and bipolar …

Recent advances in knowledge about calcium's role as an intracellular regulator promise to
broaden our understanding of possible pathophysiologic mechanisms in affective disorders. …

Medical educators had hoped that increased elective time, decreased night call, ethics courses,
and other efforts to address nontechnical issues and reduce stress in medical education …

Background While genome-wide association studies identified some promising candidates
for schizophrenia, the majority of risk genes remained unknown. We were interested in …

Depressed patients and their physicians naturally expect that each new antidepressant that
reaches the market will represent a conceptual and therapeutic advance over previous …