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Research ArticleRegular Articles

Ethanol Forensic Toxicology

Paul J. Perry, Shadi Doroudgar and Priscilla Van Dyke
Journal of the American Academy of Psychiatry and the Law Online December 2017, 45 (4) 429-438;
Paul J. Perry
Dr. Perry is a Emeritus Professor and Dr. Doroudgar is an Assistant Professor, Clinical Sciences Department, Touro University California College of Pharmacy, Vallejo, CA. Dr. Van Dyke is an Ambulatory Care Clinical Pharmacist, Kaiser Permanente, Walnut Creek, CA.
BPharm, PhD
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Shadi Doroudgar
Dr. Perry is a Emeritus Professor and Dr. Doroudgar is an Assistant Professor, Clinical Sciences Department, Touro University California College of Pharmacy, Vallejo, CA. Dr. Van Dyke is an Ambulatory Care Clinical Pharmacist, Kaiser Permanente, Walnut Creek, CA.
PharmD
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Priscilla Van Dyke
Dr. Perry is a Emeritus Professor and Dr. Doroudgar is an Assistant Professor, Clinical Sciences Department, Touro University California College of Pharmacy, Vallejo, CA. Dr. Van Dyke is an Ambulatory Care Clinical Pharmacist, Kaiser Permanente, Walnut Creek, CA.
PharmD
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    Figure 1.

    Relative probability of being responsible for a fatal automobile crash increases with rising BAC.

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    Table 1

    Distribution of Ethanol in Body Tissue and Fluid Compared With Blood

    SpecimenMultistudy AverageRange of AveragesStudies (n)
    Urine1.291.01–1.4415
    Serum or plasma1.161.12–1.184
    Vitreous humor1.140.99–1.348
    Saliva1.131.10–1.204
    Cerebrospinal fluid1.080.92–1.184
    Skeletal muscle0.900.89–0.912
    Brain0.840.62–1.249
    Kidney0.66–1
    Liver0.600.56–0.63
    • Adapted from Garriot JC, ed. Medicolegal Aspects of Alcohol (ed 3). Tucson, AZ: Lawyers & Judges Publishing Co., 1996.

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    Table 2

    Widmark ‘r’ Values by the Method of Forrest

    Height (cm)Weight (kg)Widmark Factor “r” (L/kg)
    WomenMen
    155500.680.77
    170600.680.77
    175700.650.74
    180800.630.72
    190900.630.72
    1951000.610.70
    • Adapted from Barbour AD. Simplified Estimation of Widmark “r” Values by the Method of Forrest. Sci Just 2001;41:53–54.

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    Table 3

    Correlations of BAC to Intoxication

    BAC %Intoxication
    0.01–0.05Only slight physiological impairment
    0.05–0.07Euphoria, increased self-confidence, impairment of reaction responses
    0.07–0.10Impairment of reaction sponsors, attention, visual acuity, and judgement; individual may appear sober
    0.10–0.20Increased impairment of a sensory motor activity. Reaction times, attention, visual acuity, and judgment progress to increase in drowsiness, disorientation, and emotional lability
    0.20–0.30Staggering, drunk, lethargic, sleepy or hostile, and aggressive
    0.30–0.40Unconscious or in a stupor
    +0.40Coma and possible death
    • Adapted from Rao KN. Forensic Toxicology Medico-Legal Case Studies. Boca Raton, FL: CRC Press, 2012.

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    Table 4

    Parameters Associated With a Typical Field Sobriety test

    ParameterRating
    Breath odor of ethanolVery strong, strong, moderate, faint, none
    AttitudeExcited, hilarious, talkative, carefree, sleepy, profanity, combative, indifferent, insulting, cocky, cooperative, polite
    Unusual actionsHiccups, belching, vomiting, fighting, crying, laughing
    SpeechNot understandable, muffled, slurred, mush mouthed, confused, thick tongued, stuttered, accent, fair, good
    EyesWatery, pupil dilated, bloodshot, red eyelids, apparently normal
    BalanceFalling, needing support, wobbling, swaying, unsure, fair, sure
    Horizontal gaze, nystagmus (i.e., smooth pursuit)a. Pencil held horizontally 12–15 inches from nose
    b. Over 6 seconds, move pencil to the extreme left and right of eye field, repeat × 2
    c. Subject observed for “lack of smooth pursuit” (i.e., no jerking or tremor eyeball)
    d. Jerk at maximum deviation
    e. Hold pencil at maximum for 4 seconds and observe for jerking toward center
    Reaction to lightIf no drugs are present, the pupils should constrict within 1 second after penlight beam strikes the eye
    Balance (walk and turn)a. Read instructions (don't start until instructions are finished)
    b. Rated as follows: starts too soon or cannot keep balance
    c. Walking stage (rate 1st 9 steps and 2nd 9 steps)
    d. Rated as follows: misses heel to toe, steps off imaginary line, raises arms, number of steps taken
    One-leg standa. Stand for 30 seconds with the left foot raised 6 inches off the ground
    b. Rated at 0–10, 11–20, 21–30 seconds for: swaying, raising arms, hopping, foot down
    Quality of the speech (say the ABCs)Slurred or thickened speech
    Finger-to-noseAssess motor coordination
    Finger countCounting fingers then touching thumb forward and backward
    Counting backwardAssess thought processes and concentration
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Journal of the American Academy of Psychiatry and the Law Online: 45 (4)
Journal of the American Academy of Psychiatry and the Law Online
Vol. 45, Issue 4
1 Dec 2017
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Ethanol Forensic Toxicology
Paul J. Perry, Shadi Doroudgar, Priscilla Van Dyke
Journal of the American Academy of Psychiatry and the Law Online Dec 2017, 45 (4) 429-438;

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Ethanol Forensic Toxicology
Paul J. Perry, Shadi Doroudgar, Priscilla Van Dyke
Journal of the American Academy of Psychiatry and the Law Online Dec 2017, 45 (4) 429-438;
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