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Research ArticleRegular Articles

Neurocognitive Deficits Associated with Antisocial Personality Disorder in Non-treatment-seeking Young Adults

Samuel R. Chamberlain, Katie L. Derbyshire, Eric W. Leppink and Jon E. Grant
Journal of the American Academy of Psychiatry and the Law Online June 2016, 44 (2) 218-225;
Samuel R. Chamberlain
Dr. Chamberlain is a Clinical Lecturer, Honorary Specialty Registrat (SpR), Department of Psychiatry, University of Cambridge and Cambridge and Peterborough NHS Foundation Trust, Cambridge, UK. Ms. Derbyshire and Mr. Lippink are Research Specialists and Dr. Grant is Professor, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL. This research was supported by a Center for Excellence in Gambling Research grant by the Institute for Responsible Gaming (U.S.) to Dr. Grant. Dr. Chamberlain's involvement in this study was supported by a grant from the Academy of Medical Sciences (U.K.). The funding agency had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
MD, PhD
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Katie L. Derbyshire
Dr. Chamberlain is a Clinical Lecturer, Honorary Specialty Registrat (SpR), Department of Psychiatry, University of Cambridge and Cambridge and Peterborough NHS Foundation Trust, Cambridge, UK. Ms. Derbyshire and Mr. Lippink are Research Specialists and Dr. Grant is Professor, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL. This research was supported by a Center for Excellence in Gambling Research grant by the Institute for Responsible Gaming (U.S.) to Dr. Grant. Dr. Chamberlain's involvement in this study was supported by a grant from the Academy of Medical Sciences (U.K.). The funding agency had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
BS
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Eric W. Leppink
Dr. Chamberlain is a Clinical Lecturer, Honorary Specialty Registrat (SpR), Department of Psychiatry, University of Cambridge and Cambridge and Peterborough NHS Foundation Trust, Cambridge, UK. Ms. Derbyshire and Mr. Lippink are Research Specialists and Dr. Grant is Professor, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL. This research was supported by a Center for Excellence in Gambling Research grant by the Institute for Responsible Gaming (U.S.) to Dr. Grant. Dr. Chamberlain's involvement in this study was supported by a grant from the Academy of Medical Sciences (U.K.). The funding agency had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
BA
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Jon E. Grant
Dr. Chamberlain is a Clinical Lecturer, Honorary Specialty Registrat (SpR), Department of Psychiatry, University of Cambridge and Cambridge and Peterborough NHS Foundation Trust, Cambridge, UK. Ms. Derbyshire and Mr. Lippink are Research Specialists and Dr. Grant is Professor, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL. This research was supported by a Center for Excellence in Gambling Research grant by the Institute for Responsible Gaming (U.S.) to Dr. Grant. Dr. Chamberlain's involvement in this study was supported by a grant from the Academy of Medical Sciences (U.K.). The funding agency had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
JD, MD, MPH
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    Table 1

    Demographics and Clinical Variables of Young Adults With Antisocial Personality Disorder

    VariableAntisocial Personality Disorder (n = 17)Controls (n = 229)pd
    Age, years23.8 (3.9)23.6 (3.1)0.763
    Gender, male, n (%)10 (58.8)141 (61.6)0.823c
    Education scorea2.7 (0.8)2.9 (0.8)0.087
    Unemployed? yes, n (%)6 (35.3)28 (12.2)0.008c0.170
    Married? yes, n (%)1 (5.9)9 (4.9)0.694c
    Previous illegal acts, yes, n (%)16 (94.1)12 (5.2)<0.001c0.710
    SCI-PG score3.2 (3.1)1.4 (1.9)<0.0010.70
    Current alcohol use, drinks per week1.1 (0.9)1.6 (1.6)0.219
    Current nicotine use, packs per day0.43 (0.59)0.17 (0.31)0.0020.55
    Any current psychiatric comorbidity (besides substance use disorder), n (%)b5 (29.4)36 (15.7)0.144c
    • All data are expressed as the mean (SD) except where indicated. d = Cohen's d effect size, except for chi-square when phi is used to denote effect size. Statistical significance was determined by independent-samples t tests except where indicated ‘c’ (chi-square). Significance was set at p < 0.05.

    • ↵a 1, below high-school; 2, high-school graduate; some college; 4, college graduate; and 5, higher than college level education.

    • ↵b The number of participants with the given Axis I disorders in the ASPD group were: n = 2, major depressive disorder; n = 3, agoraphobia; n = 1, social phobia; n = 2, posttraumatic stress disorder (PTSD); n = 1, psychosis; n = 1, bulimia; n = 1, general anxiety disorder and for controls; n = 9, major depressive disorder; n = 2, hypomanic episode; n = 4, panic disorder; n = 8, agoraphobia; n = 11, social phobia; n = 6, obsessive-compulsive disorder; n = 1, PTSD; n = 6, bulimia; n = 12, general anxiety disorder.

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    Table 2

    Measures of Impulsivity in Young Adults With Antisocial Personality Disorder

    TaskAntisocial Personality Disorder (n = 17)Controls (n = 229)pd
    BIS
        Attention impulsiveness17.6 (5.3)16.4 (4.2)0.265
        Motor impulsiveness25.8 (7.3)23.5 (4.9)0.081
        Nonplanning impulsiveness24.4 (7.0)24.4 (6.0)0.958
    EIQ
        Impulsivity13.4 (5.7)9.8 (5.8)0.0150.63
        Venturesomeness18.9 (7.5)13.9 (7.0)0.0050.69
        Empathy18.3 (9.3)14.8 (7.2)0.057
    IDED total errors (adjusted)30.4 (21.5)26.1 (26.0)0.516
    SST SSRT216.6 (82.0)182.2 (61.9)0.0320.47
    SST median correct RT on GO trials529.0 (255.1)475.8 (152.1)0.190
    CGT Risk adjustment0.73 (0.86)1.40 (1.21)0.0250.64
    CGT overall proportion bet0.580 (0.162)0.547 (0.138)0.352
    CGT quality of decision making0.931 (0.068)0.934 (0.102)0.878
    SWM strategy33.2 (5.1)30.7 (6.2)0.105
    SWM total errors27.5 (20.9)20.2 (18.7)0.129
    OTS Problems solved on first choice15.9 (4.5)17.4 (3.9)0.128
    • All data are expressed as the mean (SD). Significance was set at p < 0.05. BIS, Barratt Impulsivity Scale; EIQ, Eysenck Impulsivity Questionnaire; IDED, Intradimensional/Extradimensional Set-Shift Task; SST, Stop-Signal Task; CGT, Cambridge Gamble Task; SWM, Spatial Working Memory Task; OTS, One-Touch Stockings of Cambridge Task; d, Cohen's d effect size.

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Journal of the American Academy of Psychiatry and the Law Online: 44 (2)
Journal of the American Academy of Psychiatry and the Law Online
Vol. 44, Issue 2
1 Jun 2016
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Neurocognitive Deficits Associated with Antisocial Personality Disorder in Non-treatment-seeking Young Adults
Samuel R. Chamberlain, Katie L. Derbyshire, Eric W. Leppink, Jon E. Grant
Journal of the American Academy of Psychiatry and the Law Online Jun 2016, 44 (2) 218-225;

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Neurocognitive Deficits Associated with Antisocial Personality Disorder in Non-treatment-seeking Young Adults
Samuel R. Chamberlain, Katie L. Derbyshire, Eric W. Leppink, Jon E. Grant
Journal of the American Academy of Psychiatry and the Law Online Jun 2016, 44 (2) 218-225;
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