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Research ArticleRegular Articles

Long-Acting Injectable versus Oral Antipsychotics for Restoration of Competency to Stand Trial

Elias Ghossoub, Susan Minchin, Davinder Hayreh and William J. Newman
Journal of the American Academy of Psychiatry and the Law Online December 2019, 47 (4) 440-447; DOI: https://doi.org/10.29158/JAAPL.003866-19
Elias Ghossoub
Dr. Ghossoub is Assistant Professor of Clinical Psychiatry, American University of Beirut, and Dr. Newman is Professor, Forensic Psychiatry Division, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University, Saint Louis, Missouri. Drs. Minchin and Hayreh are Psychiatrists, Metropolitan Saint Louis Psychiatric Center, Saint Louis, Missouri.
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Susan Minchin
Dr. Ghossoub is Assistant Professor of Clinical Psychiatry, American University of Beirut, and Dr. Newman is Professor, Forensic Psychiatry Division, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University, Saint Louis, Missouri. Drs. Minchin and Hayreh are Psychiatrists, Metropolitan Saint Louis Psychiatric Center, Saint Louis, Missouri.
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Davinder Hayreh
Dr. Ghossoub is Assistant Professor of Clinical Psychiatry, American University of Beirut, and Dr. Newman is Professor, Forensic Psychiatry Division, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University, Saint Louis, Missouri. Drs. Minchin and Hayreh are Psychiatrists, Metropolitan Saint Louis Psychiatric Center, Saint Louis, Missouri.
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William J. Newman
Dr. Ghossoub is Assistant Professor of Clinical Psychiatry, American University of Beirut, and Dr. Newman is Professor, Forensic Psychiatry Division, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University, Saint Louis, Missouri. Drs. Minchin and Hayreh are Psychiatrists, Metropolitan Saint Louis Psychiatric Center, Saint Louis, Missouri.
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    Table 1

    Sociodemographic, Clinical, and Legal Characteristics by Outcome of Competency Restoration

    CharacteristicCSTPISTp
    Age, median (IQR)36.2 (19.3)37.8 (28.3).042
    Time to decision, median (IQR)135.0 (92.0)182.0 (155.0)< .001
    Length of stay, median (IQR)165.5 (103.0)465.0 (280.0)< .001
    Male197 (80.7)54 (85.7).362
    Race.080
        Non-Hispanic white144 (59.0)33 (53.2)
        Non-Hispanic black88 (36.1)29 (46.0)
    Main psychiatric discharge diagnosis.108
        Schizophrenia spectrum and other psychotic disorders169 (69.8)42 (66.7)
        Bipolar and related disorders26 (10.7)3 (4.8)
        Depressive disorders7 (2.9)1 (1.6)
        Neurocognitive disorders5 (2.1)7 (11.1)
        Neurodevelopmental disorders8 (3.3)6 (9.5)
        Anxiety disorders4 (1.7)1 (1.6)
        Trauma- and stressor-related disorders4 (1.7)0 (0.0)
        Substance-related and addictive disorders2 (0.8)0 (0.0)
        Personality disorders2 (0.8)0 (0.0)
        Malingering2 (0.8)0 (0.0)
        Disruptive, impulse-control, and conduct disorders1 (0.4)0 (0.0)
        None12 (5.0)3 (4.8)
    Type of charge.670
        Felony152 (62.3)42 (67.7)
        Misdemeanor37 (15.2)7 (11.3)
        Both55 (22.5)13 (21.0)
    Prior psychiatric treatment218 (89.3)47 (74.6).004
    • n = 244 deemed competent to stand trial; n = 63 deemed permanently incompetent to stand trial. Data are shown as n (%) unless otherwise noted.

    • CST, competent to stand trial; PIST, permanently incompetent to stand trial; IQR, interquartile range.

    • View popup
    Table 2

    Psychotropic Use by Outcome of Competency Restoration

    CSTPISTp
    Antipsychotic use through stay
        Formulation.027
            Oral146 (59.8)31 (49.2)
            LAI ± oral74 (30.3)18 (28.6)
        Class< .001
            Typical23 (9.4)4 (6.4)
            Atypical117 (48.0)11 (17.5)
            Both80 (32.8)34 (54.0)
        Formulation × Class< .001
            Typical oral11 (4.5)3 (4.8)
            Atypical oral95 (38.9)9 (14.3)
            Typical and atypical oral40 (16.4)19 (30.2)
            Typical LAI ± oral12 (4.9)1 (1.6)
            Atypical LAI ± oral22 (9.0)2 (3.2)
            Typical and atypical LAI ± oral40 (16.4)15 (23.8)
    Number of antipsychotics through stay< .001
        One79 (32.4)6 (9.5)
        Two or more141 (57.8)43 (68.3)
    Psychiatric medications upon discharge
        Antipsychotics188 (77.1)45 (71.4).352
        Mood stabilizers47 (19.3)26 (41.3)< .001
        Antidepressants69 (28.3)15 (23.8).529
    • n = 244 deemed competent to stand trial; n = 63 deemed permanently incompetent to stand trial. Data are shown as n (%).

    • CST, competent to stand trial; PIST, permanently incompetent to stand trial; LAI, long-acting injectable.

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    Table 3

    Sociodemographic, Clinical and Legal Characteristics of the Psychosis Sample by Outcome of Competency restoration

    CharacteristicCSTPISTp
    Age, median (IQR)36.09 (14.7)36.96 (24.6).208
    Time to decision, median (IQR)142.00 (88.0)203.00 (186.3)< .001
    Length of stay, median (IQR)171.00 (108.0)484.00 (279.3)< .001
    Male136 (81.4)35 (83.3).776
    Race.522
        Non-Hispanic white89 (53.3)23 (54.8)
        Non-Hispanic black70 (41.9)19 (45.2)
    Type of charge.537
        Felony99 (59.3)28 (66.7)
        Misdemeanor30 (18.0)5 (11.9)
        Both38 (22.8)8 (19.1)
    Prior psychiatric treatment151 (90.4)40 (95.2).538
    • n = 167 deemed competent to stand trial; n = 42 deemed permanently incompetent to stand trial. Data are shown as n (%) unless otherwise noted.

    • CST, competent to stand trial; PIST, permanently incompetent to stand trial; IQR, interquartile range.

    • View popup
    Table 4

    Psychotropic Use in the Psychosis Sample by Outcome of Competency Restoration

    CSTPISTp
    Antipsychotic use through stay
        Formulation.689
            Oral105 (62.9)25 (59.5)
            LAI ± oral62 (37.1)17 (40.5)
        Class< .001
            Typical16 (9.6)1 (2.4)
            Atypical88 (52.7)11 (26.2)
            Both63 (37.7)30 (71.4)
        Formulation × Class.007
            Typical oral7 (4.2)0 (0.0)
            Atypical oral68 (40.7)9 (21.4)
            Typical and atypical oral30 (18.0)16 (38.1)
            Typical LAI ± oral9 (5.4)1 (2.4)
            Atypical LAI ± oral20 (12.0)2 (4.8)
            Typical and atypical LAI ± oral33 (19.8)14 (33.3)
    Number of antipsychotics through stay.004
        One52 (31.1)3 (7.1)
        Two or more115 (68.9)39 (92.9)
    Psychiatric medications upon discharge
        Antipsychotics150 (89.8)40 (95.2).376
        Mood stabilizers30 (19.2)19 (45.2)< .001
        Antidepressants49 (29.3)11 (26.2).687
    • n = 167 deemed competent to stand trial; n = 42 deemed permanently incompetent to stand trial. Data are shown as n (%) unless otherwise noted.

    • CST, competent to stand trial; PIST, permanently incompetent to stand trial; LAI, long-acting injectable.

    • View popup
    Table 5

    Logistic Regression Analyses of Being CST on Antipsychotic Use Through Stay

    Unadjusted ModelAdjusted Model 1*Adjusted Model 2†
    Formulation
        Oral‡–––
        LAI ± oral0.84 (0.42–1.69)0.81 (0.40–1.64)1.39 (0.58–3.34)
    Class
        Typical‡–––
        Atypical0.51 (0.06–4.24)0.52 (0.06–4.36)2.05 (0.15–28.14)
        Both0.13 (0.02–1.06)0.11 (0.01–0.91)1.26 (0.08–20.66)
    Formulation × Class
        Atypical oral‡–––
        Atypical LAI ± oral1.23 (0.24–6.19)1.25 (0.24–6.47)1.30 (0.16–10.51)
        Typical and atypical oral‡–––
        Typical and atypical LAI ± oral1.31 (0.54–3.14)1.25 (0.51–3.11)1.60 (0.56–4.57)
    • Data are presented as odds ratios (95% confidence intervals).

    • ↵* Adjusted for age at admission, sex, and race/ethnicity.

    • ↵† Adjusted for age at admission, sex, race/ethnicity, time to decision, number of antipsychotics used through stay, and use of mood stabilizers upon discharge.

    • ↵‡ Reference characteristic.

    • CST, competent to stand trial; LAI, long-acting injectable.

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Journal of the American Academy of Psychiatry and the Law Online: 47 (4)
Journal of the American Academy of Psychiatry and the Law Online
Vol. 47, Issue 4
1 Dec 2019
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Long-Acting Injectable versus Oral Antipsychotics for Restoration of Competency to Stand Trial
Elias Ghossoub, Susan Minchin, Davinder Hayreh, William J. Newman
Journal of the American Academy of Psychiatry and the Law Online Dec 2019, 47 (4) 440-447; DOI: 10.29158/JAAPL.003866-19

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Long-Acting Injectable versus Oral Antipsychotics for Restoration of Competency to Stand Trial
Elias Ghossoub, Susan Minchin, Davinder Hayreh, William J. Newman
Journal of the American Academy of Psychiatry and the Law Online Dec 2019, 47 (4) 440-447; DOI: 10.29158/JAAPL.003866-19
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